Results 271 to 280 of about 2,659,590 (353)

Effect of cannabinoids on glutamate levels in the human brain: a systematic review and meta-analysis. [PDF]

J Cannabis Res
Urbi B, Sapaen V, Hughes I, Owusu MA, Sabet A, Broadley SA.   +5 more
europepmc   +1 more source

Galactose‐Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells

ChemBioChem, EarlyView.
Glutathione‐functionalized gold nanoparticles are shown to reduce radicals in SH‐SY5Y and C6 cells. Conjugation of galactose to the outer shell improves internalization through the GLUT transporter, thus providing a smart multivalent system able to reduce oxidative stress in neuroblastoma and rat glioma cells.
Francesca Milano, Alessia Nito, Annalisa Caputo, Antonio Gaballo, Marco Marradi, Alessandra Quarta, Andrea Ragusa   +6 more
wiley   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, EarlyView.
Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki, Jumpei Sasabe   +4 more
wiley   +1 more source

Neurobiological Mechanisms of Electroconvulsive Therapy: Molecular Perspectives of Brain Stimulation. [PDF]

Int J Mol Sci
Fetahovic E, Janjic V, Muric M, Jovicic N, Radmanovic B, Rosic G, Selakovic D, Filipovic M, Muric N.   +8 more
europepmc   +1 more source

An Alternative Mechanistic Paradigm for the Electrochemical C‐Terminal Decarboxylation of Peptides

ChemElectroChem, EarlyView.
Chemoselectivity in electrochemical oxidations is largely influenced by oxidation potential which represents a challenge for selectively oxidizing higher potential functional groups in complex substrates. Herein, a molecular binding strategy that selectively oxidizes the C‐terminal acid of a model peptide containing an electron‐rich tyrosine residue by
Adam J. Sowers, Kevin D. Moeller, Kim S. Halskov   +2 more
wiley   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity. [PDF]

Cells
Paiva BS, Neves D, Tomé D, Costa FJ, Bruno IC, Trigo D, Silva RM, Almeida RD.   +7 more
europepmc   +1 more source

Functionally distinct evoked and spontaneous neurotransmission operate via a shared pool of synaptic vesicles in viscerosensory afferents. [PDF]

J Physiol
Arnold RA, Peters JH.
europepmc   +1 more source