Results 31 to 40 of about 314,032 (295)
Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]
, 2015 Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA +4 more
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Glutamate receptor pores [PDF]
The Journal of Physiology, 2014 AbstractGlutamate receptors are ligand‐gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo‐ or heteromeric tetramers with each subunit contributing a re‐entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction
openaire +2 more sources
Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Lumeng J, Yu +3 more
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Molecular Pain, 2020 Temporomandibular joint disorder is a common chronic craniofacial pain condition, often involving persistent, widespread craniofacial muscle pain.
Man-Kyo Chung, Jin Y Ro
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Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]
, 2019 FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran +14 more
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013 The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate.
V. N. Ochkolyas +3 more
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Frontiers in Neuroscience, 2021 Glutamate signalling is an essential aspect of neuronal communication involving many different glutamate receptors, and underlies the processes of memory, learning and synaptic plasticity.
Richard Fairless +4 more
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C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors [PDF]
, 2000 NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses.
Kennedy, Mary B. +5 more
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Astroglial Glutamate Signaling and Uptake in the Hippocampus
Frontiers in Molecular Neuroscience, 2018 Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond
Christine R. Rose +7 more
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Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
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