Results 11 to 20 of about 230,640 (243)

Glycine Transporters and Receptors as Targets for Analgesics [PDF]

Biomolecules, 2021
The suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain has gained widespread recognition, with glycine receptors (GlyRs) and glycine transporters (GlyT1 and GlyT2) now considered key therapeutic targets [...]
Robert J. Harvey, Robert J. Vandenberg
openaire   +4 more sources

Glycine increases the number of somatostatin receptors and somatostatin-mediated inhibition of the adenylate cyclase system in the rat hippocampus [PDF]

, 1996
The glycine and somatostatin (SS) neurotransmission systems in the brain have been implicated in the function of sensory, motor, and nociceptive pathways.
Arilla Ferreiro, Eduardo, Puebla Jiménez, Lilian   +1 more
core   +2 more sources

Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials [PDF]

, 2017
BACKGROUND: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function.
Hwei-Hsien Chen, Mei-Yi Lee, Ming-Huan Chan, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng   +5 more
core   +1 more source

Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]

, 2015
Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert, Hodges, Matthew, Miller, Justin Robert, Muere, Clarissa, Neumueller, Suzanne, Olesiak, Samantha, Pan, Lawrence   +6 more
core   +2 more sources

BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS [PDF]

British Journal of Pharmacology, 1976
In cats, anaesthetized with pentobarbitone, intravenous diazepam (minimum dose 3.0 mg/kg) enhanced dorsal root potentials but did not significantly diminish the reduction by electrophoretic strychnine of the inhibitory action of electrophoretic glycine on dorsal horn interneurones.
David R. Curtis, D. Lodge, C. J. A. Game
openaire   +3 more sources

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
core   +1 more source

The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement [PDF]

, 2013
Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward ...
A Agrawal, A Malmberg, A Schosser, AA Grace, AC Tziortzi, Allison Nugent, Andreas Reif, Anthony A. Grace, AS Henderson, B Lerer, BH Schott, C Martin-Soelch, C Toma, CA Hodgkinson, CA Zarate Jr, CB Aiken, CH Lammers, Chantal Martin-Soelch, Colin A. Hodgkinson, D Martinez, David Goldman, DG Dikeos, DG Dikeos, DH Zald, DJ Vandenbergh, DM Segal, EA Rabiner, EG Jonsson, EG Jonsson, EV Gurevich, F Jeanneteau, F Sambataro, F Zhang, FK Maina, G Novak, GF Rowlands, H Deng, HN Koenig, I Bombin, J Costas, J Diaz, J Joutsa, J Maj, J Wei, JC Barrett, Joanna Szczepanik, Jonathan Savitz, JW Buckholtz, L Heimer, LM Oswald, M Hirvonen, M Laruelle, M Papp, M Pecina, MA Khaled, MJ Koepp, ML Bouthenet, NA Lassen, ND Volkow, ND Volkow, NE Goeders, NS Bamford, O Chernoloz, O Valenti, P Proitsi, P Sokoloff, Pei-Hong Shen, Peter Herscovitch, PM Fisher, R Bogdan, R Hwang, RA Rhodes, RE Carson, RG Shulman, RH Perlis, S Pappata, S Ridray, S Taylor, S Tsuchimine, SN Haber, T Kienast, T Pohjalainen, U Dannlowski, V Vengeliene, W Schultz, Wayne C. Drevets, WC Drevets, X Liu, Y Goto, YZ Liu, ZX Xi   +90 more
core   +6 more sources

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Identification of critical residues in loop E in the 5-HT(3AS)R binding site [PDF]

, 2002
BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity.
Joshi, Prasad R, Muthalagi, Mani, Schulte, Marvin K, Venkatachalan, Srinivasan P, Venkataraman, Padmavati   +4 more
core   +3 more sources

Glycine Receptors in Spinal Nociceptive Control—An Update [PDF]

Biomolecules, 2021
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain states. Restoring proper synaptic inhibition is a well-established rational therapeutic approach explored by several pharmaceutical companies. A particular challenge arises from the need for site-specific intervention to avoid deleterious side effects such ...
Zeilhofer, Hanns Ulrich, Werynska, Karolina, Gingras, Jacinthe, Yévenes, Gonzalo E   +3 more
openaire   +6 more sources