Results 31 to 40 of about 3,076,380 (339)
Functional recovery of glycine receptors in spastic murine model of startle disease
Neurobiology of Disease, 2006 Clinical variability is common in inherited gene defects of the central nervous system in humans and in animal models of human disorders. Here, we used the homozygous spastic (spa) mutant mice, which resemble human hereditary hyperekplexia, to determine ...
Annamaria Molon +4 more
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Journal of Neuroinflammation, 2020 Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas +4 more
doaj +1 more source
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]
, 2017 The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
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Amino acids integrate behaviors in nerveless placozoans
Frontiers in Neuroscience, 2023 Placozoans are the simplest known free-living animals without recognized neurons and muscles but a complex behavioral repertoire. However, mechanisms and cellular bases of behavioral coordination are unknown.
Mikhail A. Nikitin +4 more
doaj +1 more source
The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development [PDF]
, 2010 Throughout development GABAB receptors (GABABRs) are widely expressed in the mammalian brain. In mature auditory brainstem neurons, GABABRs are involved in the short-term regulation of the strength and dynamics of excitatory and inhibitory inputs, thus ...
Grothe, Benedikt +2 more
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A quantitative study of inhibitory interneurons in laminae I-III of the mouse spinal dorsal horn [PDF]
, 2013 Laminae I-III of the spinal dorsal horn contain many inhibitory interneurons that use GABA and/or glycine as a neurotransmitter. Distinct neurochemical populations can be recognised among these cells, and these populations are likely to have differing ...
Durrieux, C. +3 more
core +5 more sources
Glycine-dependent activation of NMDA receptors
The Journal of General Physiology, 2015 Results from single-molecule and macroscopic electrophysiology and kinetic analysis provide a model for activation of the glutamate-bound NMDA receptor by glycine.
Kirstie A. Cummings, G. Popescu
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2010 Recent evidence indicates that strychnine-sensitive glycine receptors are located in upper brain regions including the hippocampus. Because of excitatory effects of glycine via facilitation of NMDA-receptor function, however, the net effects of increased
Mitsuo Tanabe, Azusa Nitta, Hideki Ono
doaj +1 more source
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]
PLoS ONE, 2011 Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen +3 more
doaj +1 more source
New immunolatex spheres: visual markers of antigens on lymphocytes for scanning electron microscopy [PDF]
, 1975 New immunochemical reagents consisting of antibodies bound to small latex spheres were used as visual markers for the detection and localization of cell surface antigens by scanning electron microscopy.
Dreyer, William J. +3 more
core +2 more sources