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Cells, 2023 Integrins were originally identified as receptors for extracellular matrix (ECM) and cell-surface molecules (e.g., VCAM-1 and ICAM-1). Later, we discovered that many soluble growth factors/cytokines bind to integrins and play a critical role in growth ...
Yoshikazu Takada +2 more
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F1000ResearchFibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler +2 more
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Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]
Veterinary World, 2016 Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval +4 more
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FASEB BioAdvances, 2020 Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to
Hubert Hondermarck +2 more
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Patologìâ, 2014 Aim. In immunohistochemical research of biopsy and postoperative material of 120 patients with the pancreatic ductal adenocarcinoma the levels of growth receptors of ErbB family and cancer prognostic markers expression were determined.
V. A. Tumanskiy , A. V. Evseyev
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Di-san junyi daxue xuebao, 2019 Objective To investigate the changes in the expression of fibroblast growth factor receptors 1-3 (FGFR1-3) at different stages of osteogenic differentiation and clarify the role of FGFR signaling in osteogenic differentiation.
MO Qifei, YANG Peng, SU Nan, CHEN Lin
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Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death
Cells, 2021 Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao +3 more
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Fibroblast growth factor receptors in breast cancer
Tumor Biology, 2017 Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
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Indian Journal of Medical and Paediatric Oncology, 2017 Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally,
Periyasamy Amutha, Thangarajan Rajkumar
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Nanodelivery Systems Targeting Epidermal Growth Factor Receptors for Glioma Management
Pharmaceutics, 2020 A paradigm shift in treating the most aggressive and malignant form of glioma is continuously evolving; however, these strategies do not provide a better life and survival index.
Sathishbabu Paranthaman +7 more
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