Results 1 to 10 of about 850,111 (294)

Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand

Cells, 2023
Integrins were originally identified as receptors for extracellular matrix (ECM) and cell-surface molecules (e.g., VCAM-1 and ICAM-1). Later, we discovered that many soluble growth factors/cytokines bind to integrins and play a critical role in growth ...
Yoshikazu Takada, Masaaki Fujita, Yoko K. Takada   +2 more
doaj   +1 more source

Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]

Veterinary World, 2016
Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval , Ratn D. Singh , Dilip V. Joshi , Hitesh B. Patel , Shailesh K. Mody   +4 more
doaj   +1 more source

The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?

FASEB BioAdvances, 2020
Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to
Hubert Hondermarck, Nathan W. Bartlett, Victor Nurcombe   +2 more
doaj   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

Expression of fibroblast growth factor receptor and its role in regulating osteoblast differentiation

Di-san junyi daxue xuebao, 2019
Objective To investigate the changes in the expression of fibroblast growth factor receptors 1-3 (FGFR1-3) at different stages of osteogenic differentiation and clarify the role of FGFR signaling in osteogenic differentiation.
MO Qifei, YANG Peng, SU Nan, CHEN Lin
doaj   +1 more source

Nanodelivery Systems Targeting Epidermal Growth Factor Receptors for Glioma Management

Pharmaceutics, 2020
A paradigm shift in treating the most aggressive and malignant form of glioma is continuously evolving; however, these strategies do not provide a better life and survival index.
Sathishbabu Paranthaman, Meghana Goravinahalli Shivananjegowda, Manohar Mahadev, Afrasim Moin, Shivakumar Hagalavadi Nanjappa, Nandakumar Dalavaikodihalli Nanjaiyah, Saravana Babu Chidambaram, Devegowda Vishakante Gowda   +7 more
doaj   +1 more source

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death

Cells, 2021
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen   +3 more
doaj   +1 more source

Colocalization of somatostatin receptors and epidermal growth factor receptors in breast cancer cells

Cancer Cell International, 2006
Background Somatostatin receptor (SSTR) expression is positively correlated with tumor size and inversely correlated with epidermal growth factor receptor (ErbB) levels and tumor differentiation. In the present study, we compared SSTR1-5 and ErbB1-4 mRNA
Kumar Ujendra, Watt Heather L
doaj   +1 more source

Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer. [PDF]

PLoS ONE, 2013
INTRODUCTION: Male breast cancer accounts for 0.5-1% of all breast cancers and is generally diagnosed at higher stage than female breast cancers and therefore might benefit from earlier detection and targeted therapy.
Jeroen F Vermeulen, Robert Kornegoor, Elsken van der Wall, Petra van der Groep, Paul J van Diest   +4 more
doaj   +1 more source

The impact of high density receptor clusters on VEGF signaling [PDF]

EPTCS 125, 2013, pp. 37-52, 2013
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv   +1 more source