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Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
Cells, 2019 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai +4 more
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Functions of fibroblast growth factors and their receptors [PDF]
Current Biology, 1995 Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A +3 more
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Identification of kinases activated by multiple pro-angiogenic growth factors
Frontiers in Pharmacology, 2023 Antiangiogenic therapy began as an effort to inhibit VEGF signaling, which was thought to be the sole factor driving tumor angiogenesis. It has become clear that there are more pro-angiogenic growth factors that can substitute for VEGF during tumor ...
Scott Gruver +3 more
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Kidney Diseases, 2020 Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they
Liu Feng +9 more
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The hepatocyte growth factor and its receptor [PDF]
STEM CELLS, 1996 Hepatocyte growth factor/scatter factor (HGF/SF) is secreted by cells of mesodermal origin and shows powerful mitogenic, motogenic and morphogenic activities on epithelial and endothelial cells. It is a heparin-binding polypeptide with an alpha/beta heterodimeric structure, showing structural homologies with enzymes of the blood clotting cascade.
GALIMI F. +2 more
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The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]
Journal of Urologic OncologyDysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo +3 more
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Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics [PDF]
Biophysical Journal 76, 188 (1999), 1999 Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational changes in the protein which induce transactivation or transrepression of the target genes.
arxiv +1 more source
Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
BMC Pulmonary Medicine, 2005 Background Hepatocyte and keratinocyte growth factors are key growth factors in the process of alveolar repair. We hypothesized that excessive alveolar destruction observed in lung emphysema involves impaired expression of hepatocyte and keratinocyte ...
Marchal Joëlle +8 more
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Identification and super-resolution imaging of ligand-activated receptor dimers in live cells [PDF]
Scientific Reports 3 (2013) 2387, 2013 Molecular interactions are key to many chemical and biological processes like protein function. In many signaling processes they occur in sub-cellular areas displaying nanoscale organizations and involving molecular assemblies. The nanometric dimensions and the dynamic nature of the interactions make their investigations complex in live cells.
arxiv +1 more source
Magnetic Iron Nanocubes Effectively Capture Epithelial and Mesenchymal Cancer Cells [PDF]
ACS Omega 2020, 5, 37, 23724 23735, 2020 Current methods for capturing circulating tumor cells (CTCs) are based on the overexpression of cytokeratin (CK) or epithelial cell-adhesion molecule (EpCAM) on cancer cells. However, during the process of metastasis, tumor cells undergo epithelial to mesenchymal transition (EMT) that can lead to the loss of CK/EpCAM expression.
arxiv +1 more source