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Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor
Biochemistry, 1996The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
J M, Sherrill, J, Kyte
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1988
Growth factors and growth factor receptors may be involved in the abnormal growth characteristic of cancer, and both entities are encoded by known proto-oncogenes. Growth factors may act as self-stimulants (autocrine control stimulants of nearby cells(paracrine control), or stimulants of distant tissue (hormonal control).
Kathy B. Burck +2 more
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Growth factors and growth factor receptors may be involved in the abnormal growth characteristic of cancer, and both entities are encoded by known proto-oncogenes. Growth factors may act as self-stimulants (autocrine control stimulants of nearby cells(paracrine control), or stimulants of distant tissue (hormonal control).
Kathy B. Burck +2 more
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Transforming growth factor-? receptors
Cytotechnology, 1989Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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Vascular endothelial growth factor (VEGF) and its receptors
The FASEB Journal, 1999G. Neufeld +3 more
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH
Endocrinology and Metabolism Clinics of North America, 1996The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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Epidermal growth factor-related peptides and their receptors in human malignancies.
Critical reviews in oncology/hematology, 1995D. Salomon +3 more
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Cellular signaling by fibroblast growth factor receptors.
Cytokine & growth factor reviews, 2005V. P. Eswarakumar +2 more
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The epidermal growth factor/transforming growth factor-?? family and their receptors
European Journal of Gastroenterology & Hepatology, 1995Cytokines and growth factors act as intercellular signalling molecules which control cellular functions during development and in response to injury or infection. The epidermal growth factor (EGF) family is an expanding group of structurally related polypeptides that regulate cell proliferation, migration and differentiation, via tyrosine kinase ...
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