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Growth factors and receptors in cancer
Current Opinion in Biotechnology, 1991There have been a number of recent developments in mechanisms of action of growth factors and their receptors with particular relevance to cancer. The tyrosine kinase receptor family, in particular, has been shown to be important in tumour growth. These receptors are the products of oncogenes, or can interact with other oncogene pathways.
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Signal Transduction by Growth Factor Receptors [PDF]
, 1986 The proliferation of cells in vivo and in culture is tightly regulated by polypeptide growth factors. Like all polypeptide hormones, growth factors initiate their action by binding to specific, high affinity receptor molecules on the cell surface. Interest in growth factors and their receptors has been dramatically intensified by the discovery that at ...
W. H. Moolenaar +4 more
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Regulation of Growth Factor Receptors by Gangliosides
Science Signaling, 2002Since their discovery in the 1940s, gangliosides have been associated with a number of biological processes, such as growth, differentiation, and toxin uptake. Hypotheses about regulation of these processes by gangliosides are based on indirect observations and lack a clear definition of their mechanisms within the cell.
Eric G. Bremer +3 more
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Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor
Biochemistry, 1996The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
Jennifer Miller Sherrill, Jack Kyte
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Transforming growth factor-? receptors
Cytotechnology, 1989Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH
Endocrinology and Metabolism Clinics of North America, 1996The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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Epidermal growth factor receptor ≠ nerve growth factor
Neurobiology of Aging, 1989I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating ...
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Pancreatic Cancer: Growth Factors and Growth Factor Receptors
1999Cancer of the pancreas presently has an incidence of approximately 8 to 10 cases per 100 000 citizens in industrialised European countries (1), an incidence that has been increasing over the past decades (2,3). In the USA the disease presently represents the fourth leading cause of cancer death in men and in women (1,4,5). Approximately 30 000 patients
Pascal O. Berberat +5 more
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Signaling by Growth Factor Receptors [PDF]
, 2004 Yosef Yarden, Bose Kochupurakkal
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