Results 111 to 120 of about 21,097 (244)
Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. [PDF]
, 2014 Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. Among the plethora of actions mediated by HA, the modulatory effects on steroidogenesis and proliferation in Leydig cells (LCs) have
Mondillo, Carolina +4 more
core +2 more sources
British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma +9 more
wiley +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Pepducins as a potential treatment strategy for asthma and COPD. [PDF]
, 2018 Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to prevent or
Benovic, Jeffrey L. +4 more
core +2 more sources
Double‐Blind Placebo Challenge Confirmation of Diphenhydramine Allergy
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Diphenhydramine, a first‐generation H1–antihistamine commonly used for allergic symptom relief and infusion premedication, rarely causes true systemic hypersensitivity. When suspected reactions are mild and subjective—particularly in anxious patients—objective confirmation is essential.
Ruchi Patel +2 more
wiley +1 more source
Frontiers in Endocrinology, 2018 Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock ...
Eri Morioka +4 more
doaj +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.ABSTRACT Background Biotherapies have transformed the management of severe asthma (SA), shifting treatment goals from disease control toward achieving clinical remission. This study aimed to evaluate the effectiveness of biotherapies in inducing remission in severe asthma and to identify baseline patient characteristics that could predict remission ...
Jeanne Vervier +12 more
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2019 Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic ...
Natalia Kordulewska +4 more
doaj +1 more source
Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.ABSTRACT Background Chronic Spontaneous Urticaria (CSU) is a debilitating skin condition characterized by recurrent wheals and pruritus, significantly impacting quality of life. Molecular mechanisms underlying different severity phenotypes are not fully understood.
Kevin Muliawan Soetanto +5 more
wiley +1 more source