Results 181 to 190 of about 696,707 (241)

Risperidone-Induced Nasal Congestion and Increased Urinary Frequency. [PDF]

Cureus
Abu Baker H, Alnuaimi B, Alkot A.
europepmc   +1 more source

When the brain talks back to the eye. [PDF]

PLoS Biol
Gonschorek D, Euler T.
europepmc   +1 more source

Restless Legs Syndrome Associated With Fexofenadine Use: A Case Report. [PDF]

Clin Case Rep
Albeshry AM.
europepmc   +1 more source

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The roles of histamine H1 receptors on cognition

Inflammation Research, 2008
Histamine neurons are located exclusively in the posterior hypothalamus, from where they project diffusely to all regions of brain. Neuronal histamine has been implicated in a variety of brain functions including wakefulness, learning and memory [1].
K, Yanai, H, Dai, E, Sakurai, T, Watanabe   +3 more
openaire   +2 more sources

Domain Swapping in the Human Histamine H1 Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2004
G-protein-coupled receptors (GPCRs) represent the largest family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms.
Bakker, R.A., Dees, G., Carrillo, J.J., Booth, R.G., Lopez-Gimenez, J.F., Milligan, G., Strange, P.G., Leurs, R.   +7 more
openaire   +2 more sources

Structural Analysis of the Histamine H1 Receptor

2016
The crystal structure of the human histamine H1 receptor (H1R) has been determined in complex with its inverse agonist doxepin, a first-generation antihistamine. The crystal structure showed that doxepin sits deeply inside the ligand-binding pocket and predominantly interacts with residues highly conserved among other aminergic receptors.
Mitsunori, Shiroishi, Takuya, Kobayashi
openaire   +2 more sources

Developments in histamine H1-receptor agonists

1995
The story of histamine started in the early 1900’s with the fundamental investigations of Dale et al. [l–3], which recognized the remarkable physiological behavior of this biogenic amine. Scientific progress over the past decades has proved that histamine interacts with specific histamine receptors as a neurotransmitter and nearly all mammalian tissues
V, Zingel, C, Leschke, W, Schunack
openaire   +2 more sources

Characterization of vascular histamine H1-receptors: Multiple affinity states of aortic histamine H1-receptor

Agents and Actions, 1985
We have shown that [3H]mepyramine labels histamine H1-receptor-binding sites in bovine aortic membranes. Further characterization of H1-receptors in this tissue was done by the interaction of an unlabelled histamine receptor agonist or antagonist, with the radioantagonist [3H]mepyramine-binding sites.
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Characteristics of histamine H1 receptors on HeLa cells

European Journal of Pharmacology: Molecular Pharmacology, 1993
The affinities of antagonists at histamine H1 receptors on HeLa cells have been determined from inhibition of histamine-induced inositol phosphate formation in intact and from inhibition of [3H]mepyramine binding to HeLa cell membranes. The dissociation constants of mepyramine and (+)-chlorpheniramine were similar to values for binding to H1 receptors ...
J A, Arias-Montaño, J M, Young
openaire   +2 more sources