Results 201 to 210 of about 12,014 (244)
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Genomic Cloning of the Rat Histamine H1 Receptor
Biochemical and Biophysical Research Communications, 1993A rat histamine H1 receptor gene which lacked introns was isolated from a rat genomic library using recently cloned bovine histamine H1 receptor cDNA [Yamashita et al., Proc. Natl. Acad. Sci. USA, 88, 11515-11519 (1991)]. The receptor protein deduced from this isolated gene was composed of 486 amino acids and showed characteristic properties of G ...
K, Fujimoto +5 more
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Histamine H1- and H2-receptors in the gastrointestinal circulation
Naunyn-Schmiedeberg's Archives of Pharmacology, 1980Evidence for the presence of specific histamine H1- and H2-receptors in the gastrointestinal circulation was obtained using histamine, 2-methylhistamine (a specific H1-agonist), 4-methylhistamine (a specific H2-agonist), and selective H1- and H2-receptor antagonists in the anesthetized dog.
G A, Charbon, H A, Brouwers, A, Sala
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Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor
Molecular Pharmacology, 2009The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R.
Karl-Friedrich, Deml +4 more
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[The H1 and H2 histamine receptors].
Allergie et immunologie, 1989Histamine is a major mediator of the allergic reactions. Histamine have different actions: contraction of smooth muscles, vascular action, increase in gastric and adrenal medulla secretion. Effects on central or peripheral nervous system are discussed. The specific H1 or H2 activity explains the different configurations of histamine. The specificity of
F, Ruff, M C, Santais
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The histamine H1‐receptor mediates the motivational effects of novelty
European Journal of Neuroscience, 2008AbstractNovelty‐induced arousal has motivational effects and can reinforce behavior. The mechanisms by which novelty acts as a reinforcer are unknown. Novelty‐induced arousal can be either rewarding or aversive dependent on its intensity and the preceding state of arousal.
ZLOMUZICA A. +10 more
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Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines
Inflammation Research, 2005The predictive efficacy of drugs in humans is frequently estimated from both a high affinity for their receptor as measured in vitro and a long plasmatic half-life. This is grossly misleading since one key parameter is missing: drug concentration at the receptor site in vivo.
M, Gillard +3 more
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Molecular modeling of the histamine H1 receptor
[1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference, 2003Summary form only given. The authors review the properties and functional characteristics of the H/sub 1/ receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris ...
C. Gerula +3 more
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Nonsedating histamine H1-receptor antagonists.
Clinical pharmacy, 1989The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine ...
K V, Mann, J P, Crowe, K J, Tietze
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