Results 81 to 90 of about 12,014 (244)

Effects of clozapine on adipokine secretions/productions and lipid droplets in 3T3-L1 adipocytes

Journal of Pharmacological Sciences, 2017
Clozapine, a second-generation antipsychotic (SGA), is a cause of side effects related to metabolic syndrome. The participation of serotonin 5-HT2C and histamine H1 receptors in the central nervous system has been reported as a mechanism of the weight ...
Tomomi Tsubai, Akira Yoshimi, Yoji Hamada, Makoto Nakao, Hiroshi Arima, Yutaka Oiso, Yukihiro Noda   +6 more
doaj   +1 more source

Rebound Pruritus and Urticaria After Discontinuation of Chronic Antihistamine Use—A Scoping Review

Clinical &Experimental Allergy, EarlyView.
Rebound pruritus and urticaria have been reported after discontinuation of chronic cetirizine or levocetirizine use only. Symptoms typically occur within 0.5–5 days after stopping therapy and appear more frequently reported in female patients. Re‐initiation of antihistamines is the most commonly effective management strategy, highlighting the need for ...
Jun Jie Benjamin Seng, Prawira Oka, Ngiap Chuan Tan   +2 more
wiley   +1 more source

Histamine H1- and H2-receptor vasodilation of canine intestinal circulation.

, 1977
Studies were conducted in anesthetized dogs to determine whether the mesenteric vasodilator response to histamine is mediated by H1 receptors alone or whether H2 receptors are also involved in the response.
B L Tepperman, L L Tague, W Pawlik, T A Miller, E D Jacobson   +4 more
core   +1 more source

Histamine, histamine receptors, and neuropathic pain relief

, 2020
Histamine, acting via distinct histamine H1, H2, H3 and H4 receptors (H1R, H2R, H3R, H4R), regulates various physiological and pathological processes, including pain.
Paul L. Chazot, Vsevolod Telezhkin, Ilona Obara, Alrashdi, Ibrahim, Chazot, Paul L., Telezhkin, Vsevolod, Obara, Ilona, Ibrahim Alrashdi   +7 more
core   +1 more source

Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice

Mediators of Inflammation, 1993
Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of ...
Nora Goren, Claudia Perez Leiros, Leonor Sterin-Borda, Enri S. Borda   +3 more
doaj   +1 more source

Homologous and Heterologous Phosphorylations of Human Histamine H1 Receptor in Intact Cells

Journal of Pharmacological Sciences, 2004
Homologous and heterologous phosphorylations of histamine H1 receptor (H1R) in intact cells were investigated using Chinese hamster ovary cells stably co-expressing c-myctagged human histamine H1 and muscarinic M3 receptors. Increase in histamine-induced
Katsuhiro Miyoshi, Nozomi Kawakami, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

Identification of Amino Acid Residues Responsible for Agonist-Induced Down-Regulation of Histamine H1 Receptors

Journal of Pharmacological Sciences, 2004
The histamine H1 receptor (H1R) level is dynamically regulated in vivo under various physiological and pathological conditions. The H1R regulation may consist of various processes, and this study focused on the process of receptor trafficking, that is ...
Shuhei Horio, Maki Ogawa, Nozomi Kawakami, Katsumi Fujimoto, Hiroyuki Fukui   +4 more
doaj   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Development of novel ligands influencing neurotransmission in the central nervous system

, 2007
The development of novel drugs targeting GPCRs is of particular interest since modulation of subfamilies of this receptor class highly influences neurotransmission in the central nervous system.
Sasse, Britta Caroline
core  

Features of the choice of antihistamine therapy for allergic diseases in children. Case report

Consilium Medicum
Allergic diseases are among the most common chronic immuno-inflammatory pathologies and are characterized by a steady trend towards an increase in morbidity both among the adult population and in pediatric practice. The significant prevalence of allergic
Olga B. Tamrazova, Evgeniia A. Glukhova, Gennady A. Novik, Gayane E. Bagramova   +3 more
doaj   +1 more source