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Nasal hyperreactivity and inflammation in perennial allergic rhinitis [PDF]
Garrelds, I.M. (Ingrid)+1 more
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Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. [PDF]
Shen Q+16 more
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Inhibition of Histamine Release by Histamine controlled by H2 Receptor [PDF]
AGENTS which increase the intracellular level of adenosine 3′-5′-monophosphate (cyclic AMP) in human leukocyte preparations such as the catecholamines, methylxanthines and prostaglandins, inhibit the antigen induced, IgE antibody mediated release of histamine from human leukocytes (basophils)1–3.
Elizabeth Gillespie+1 more
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On the mechanism of histamine H2 receptor activation.
Molecular Pharmacology, 1987The H2 receptor activation mechanism model proposed by Weinstein et al. [Mol. Pharmacol. 12:738-745 (1976)] has been considered for the set of H2 agonists. The energetics of the model proton transfer processes from a proton-donor site to the heterocycle ring of the agonist molecule and from this one to a proton acceptor site have been studied by using ...
F J, Luque, F, Illas, R, Pouplana
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Histamine H2-receptor antagonists
Baillière's Clinical Gastroenterology, 1988The first histamine H2-receptor antagonists were developed in the early 1970s, and they have a dominant role in today's management of peptic ulceration. The original regimens using either cimetidine or ranitidine attempted to control acidity across the 24 hours, but more 'modern' regimens use a large single dose of the H2-blocker in the evening, which ...
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Histamine H2-Receptor Antagonists
Nursing Clinics of North America, 1991In summary, histamine initiates acid secretion by stimulating the H2 subtype histamine receptor on parietal cells. Cimetidine, rantidine, famotidine, and nizantidine are histamine H2-receptor antagonists that block this action of histamine, reducing gastric acid output and concentration under both basal and stimulated conditions.
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