Results 201 to 210 of about 23,298 (234)
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Histamine H2 receptors and cyclic AMP in brain
Life Sciences, 1974Abstract The intravenous injection of histamine to 2–3 day old chicks resulted in a rapid and marked increase in the cyclic AMP content of the cerebral hemispheres that had been removed and frozen within 0.5s using a freeze-blowing technique. This response was not antagonized by pretreatment of the chicks with the histamine H1-receptor antagonists ...
Brenda M. Smith +2 more
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Histamine H2-receptors on single central neurones
Nature, 1975THE detection of histamine H2-receptor antagonists1,2 has provided fresh impetus to the investigation of central effects of histamine3–7 and its possible role as a neurotransmitter3,8–10. In the hypothalamus of rat and cat microelectrophoretically applied histamine excites a large number of cells.
Helmut L. Haas, U M Bucher
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Histamine H2 Receptor-Antagonists
JAMA: The Journal of the American Medical Association, 1976Histamine H 2 receptor-antagonists—burimamide, metiamide, cimetidine—are currently arousing much anticipatory excitement. The relatively recent concept that there is more than one receptor for histamine is based on the observation that pyrilamine (mepyramine) and other, older antihistamines have no effect on histamine-mediated secretion of gastric acid
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H1and H2 histamine receptors on Aplysia neurones
Nature, 1975WE have found two types of histamine receptor on neurones of the mollusc Aplysia corresponding to those already known in mammals. The presence of these specific receptors is consistent with the suggestion that histamine acts as a neurotransmitter.
Gary L. Gaubatz, David O. Carpenter
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Histamine H1 and H2-Receptors at a Ganglionic Synapse
Nature, 1973MANY humoral agents are capable of modulating synaptic transmission in sympathetic ganglia and it has been proposed that a variety of receptors are present at the ganglionic synapse (see Haefely1). There are thus many possible modulatory mechanisms at this synapse, some of which have a dual nature, the same substance being able both to facilitate and ...
M J Brimble, D I Wallis
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Antagonism of tolazoline by histamine H2-receptor blockers
Nature, 1975TOLAZOLINE (2-benzyl-2-imidazoline), a peripheral vasodilator and adrenergic blocking agent used to treat peripheral vascular disease and (formerly) hypertension, has actions similar to those of histamine, including vasodilation, pressor responses in the rabbit and stimulation of intestinal smooth muscle, gastric secretion and the heart.
Tobias O. Yellin +2 more
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Histamine H1- and H2-receptors in the gastrointestinal circulation [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 1980 Evidence for the presence of specific histamine H1- and H2-receptors in the gastrointestinal circulation was obtained using histamine, 2-methylhistamine (a specific H1-agonist), 4-methylhistamine (a specific H2-agonist), and selective H1- and H2-receptor antagonists in the anesthetized dog.
Anne Sala +2 more
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Structural elements of H1- and H2-receptors of histamine
General Pharmacology: The Vascular System, 1980Abstract This article sets out the proposed schemes of histamine H 1 - and H 2 -receptors. These schemes are based on the analysis of histamine agonists activity.
L.K. Gavrovskaya +3 more
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Metiamide—An orally active histamine H2-receptor antagonist [PDF]
Agents and Actions, 1973 Metiamide has been found to be about 10 times more active than burimamide in vitro in antagonizing histamine H2-receptors and nearly 5 times more active in vivo as an antagonist of histamine or pentagastrin-stimulated secretion. Effective oral ED50 doses for inhibition have been estimated as 25 μmole kg−1 against basal secretion in rats and 16 μmole kg−
John Colin Emmett +6 more
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Stimulation of cerebral histamine H2 receptors by clonidine
Nature, 1976CLONIDINE (2-[(2,6-dichlorophenyl)amino]-2-imidazoline) is a potent antihypertensive agent whose site of action is believed to be in the central nervous system1 but its mechanism of action is far from clear. Because of its effects on peripheral tissue, it has been generally accepted that the drug stimulates alpha-adrenergic receptors1.
Y. Audigier +2 more
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