Results 1 to 10 of about 110,666 (296)
Annals of Cardiac Anaesthesia, 2022 Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody-mediated immunologic reaction striking the acetylcholine receptors. The anesthesia concerns for patients with MG include the disease state, drug interactions, and the anesthetic ...
Amarja S Nagre +2 more
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NLRP3 Inflammasome in Cardiovascular Disease: David`s Stone against Goliath? [PDF]
Romanian Journal of Cardiology, 2021 Inflammation is involved in initiation, development and complications of the vast majority of non-communicable diseases. Recent research demonstrated that inflammation is involved in pathogenesis of all major cardiovascular diseases. Different endogenous
Serban BALANESCU +3 more
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An Inhibitory Role for Human CD96 Endodomain in T Cell Anti-Tumor Responses
Cells, 2023 Immune checkpoint blockade (ICB) therapy involves the inhibition of immune checkpoint regulators which reverses their limitation of T cell anti-tumor responses and results in long-lasting tumor regression. However, poor clinical response or tumor relapse
Chelsia Qiuxia Wang +5 more
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Killer instincts: natural killer cells as multifactorial cancer immunotherapy
Frontiers in Immunology, 2023 Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of ...
Sarah Nersesian +9 more
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The Immunology of Hormone Receptor Positive Breast Cancer [PDF]
Frontiers in Immunology, 2021 Immune checkpoint blockade (ICB) has revolutionized the treatment of cancer patients. The main focus of ICB has been on reinvigorating the adaptive immune response, namely, activating cytotoxic T cells. ICB has demonstrated only modest benefit against advanced breast cancer, as breast tumors typically establish an immune suppressive tumor ...
Jonathan Goldberg +22 more
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Pharmaceuticals, 2023 Manipulating the immune system by blocking the immune checkpoint receptors is the basis of immunotherapy, a relevant tool in current clinical oncology. The strategy of blocking the immune checkpoints (Immune Checkpoint Inhibitors, ICI) consists of using ...
Ranferi Ocaña-Guzmán +2 more
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Pattern recognition receptors and autophagy
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control ...
Ji Eun eOh, Heung Kyu eLee
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Late-onset myasthenia gravis: Is it a different clinical entity?
Neurological Sciences and Neurophysiology, 2021 Objective: The increase in the average life expectancy of humans has resulted in an increased occurrence of late-onset myasthenia gravis (LOMG). It is noticeable that the clinical, immunologic, and prognostic features of patients with LOMG are different ...
Hulya Tireli +2 more
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Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19
Biomolecules, 2021 The Ig fold has had a remarkable success in vertebrate evolution, with a presence in over 2% of human genes. The Ig fold is not just the elementary structural domain of antibodies and TCRs, it is also at the heart of a staggering 30% of immunologic cell ...
Philippe Youkharibache
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Frontiers in Genetics, 2021 The coronavirus disease 2019 (COVID-19) pandemic, induced by the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly all over the world. There is considerable variability among neonates, children, and adults in the
Bangrong Cao +4 more
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