Results 1 to 10 of about 111,735 (295)
NLRP3 Inflammasome in Cardiovascular Disease: David`s Stone against Goliath? [PDF]
Romanian Journal of Cardiology, 2021 Inflammation is involved in initiation, development and complications of the vast majority of non-communicable diseases. Recent research demonstrated that inflammation is involved in pathogenesis of all major cardiovascular diseases. Different endogenous
Serban BALANESCU +3 more
doaj +1 more source
Annals of Cardiac Anaesthesia, 2022 Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody-mediated immunologic reaction striking the acetylcholine receptors. The anesthesia concerns for patients with MG include the disease state, drug interactions, and the anesthetic ...
Amarja S Nagre +2 more
doaj +1 more source
Killer instincts: natural killer cells as multifactorial cancer immunotherapy
Frontiers in Immunology, 2023 Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of ...
Sarah Nersesian +9 more
doaj +1 more source
An Inhibitory Role for Human CD96 Endodomain in T Cell Anti-Tumor Responses
Cells, 2023 Immune checkpoint blockade (ICB) therapy involves the inhibition of immune checkpoint regulators which reverses their limitation of T cell anti-tumor responses and results in long-lasting tumor regression. However, poor clinical response or tumor relapse
Chelsia Qiuxia Wang +5 more
doaj +1 more source
Pharmaceuticals, 2023 Manipulating the immune system by blocking the immune checkpoint receptors is the basis of immunotherapy, a relevant tool in current clinical oncology. The strategy of blocking the immune checkpoints (Immune Checkpoint Inhibitors, ICI) consists of using ...
Ranferi Ocaña-Guzmán +2 more
doaj +1 more source
Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]
, 2015 Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria +4 more
core +6 more sources
Pattern recognition receptors and autophagy
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control ...
Ji Eun eOh, Heung Kyu eLee
doaj +1 more source
Late-onset myasthenia gravis: Is it a different clinical entity?
Neurological Sciences and Neurophysiology, 2021 Objective: The increase in the average life expectancy of humans has resulted in an increased occurrence of late-onset myasthenia gravis (LOMG). It is noticeable that the clinical, immunologic, and prognostic features of patients with LOMG are different ...
Hulya Tireli +2 more
doaj +1 more source
Altered distribution of mucosal NK cells during HIV infection. [PDF]
, 2012 The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s ...
Alter, G +13 more
core +2 more sources
Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19
Biomolecules, 2021 The Ig fold has had a remarkable success in vertebrate evolution, with a presence in over 2% of human genes. The Ig fold is not just the elementary structural domain of antibodies and TCRs, it is also at the heart of a staggering 30% of immunologic cell ...
Philippe Youkharibache
doaj +1 more source