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The Immunologic Downsides Associated with the Powerful Translation of Current COVID-19 Vaccine mRNA Can Be Overcome by Mucosal Vaccines [PDF]
VaccinesThe action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences ...
Maurizio Federico
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Annals of Cardiac Anaesthesia, 2022 Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody-mediated immunologic reaction striking the acetylcholine receptors. The anesthesia concerns for patients with MG include the disease state, drug interactions, and the anesthetic ...
Amarja S Nagre +2 more
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NLRP3 Inflammasome in Cardiovascular Disease: David`s Stone against Goliath? [PDF]
Romanian Journal of Cardiology, 2021 Inflammation is involved in initiation, development and complications of the vast majority of non-communicable diseases. Recent research demonstrated that inflammation is involved in pathogenesis of all major cardiovascular diseases. Different endogenous
Serban BALANESCU +3 more
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An Inhibitory Role for Human CD96 Endodomain in T Cell Anti-Tumor Responses
Cells, 2023 Immune checkpoint blockade (ICB) therapy involves the inhibition of immune checkpoint regulators which reverses their limitation of T cell anti-tumor responses and results in long-lasting tumor regression. However, poor clinical response or tumor relapse
Chelsia Qiuxia Wang +5 more
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Killer instincts: natural killer cells as multifactorial cancer immunotherapy
Frontiers in Immunology, 2023 Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of ...
Sarah Nersesian +9 more
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The Immunology of Hormone Receptor Positive Breast Cancer [PDF]
Frontiers in Immunology, 2021 Immune checkpoint blockade (ICB) has revolutionized the treatment of cancer patients. The main focus of ICB has been on reinvigorating the adaptive immune response, namely, activating cytotoxic T cells. ICB has demonstrated only modest benefit against advanced breast cancer, as breast tumors typically establish an immune suppressive tumor ...
Jonathan Goldberg +22 more
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Pharmaceuticals, 2023 Manipulating the immune system by blocking the immune checkpoint receptors is the basis of immunotherapy, a relevant tool in current clinical oncology. The strategy of blocking the immune checkpoints (Immune Checkpoint Inhibitors, ICI) consists of using ...
Ranferi Ocaña-Guzmán +2 more
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Cell surface-specific N-glycan profiling in breast cancer [PDF]
, 2013 Aberrant changes in specific glycans have been shown to be associated with immunosurveillance, tumorigenesis, tumor progression and metastasis. In this study, the N-glycan profiling of membrane proteins from human breast cancer cell lines and tissues was
Chen, Cuiying +8 more
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Late-onset myasthenia gravis: Is it a different clinical entity?
Neurological Sciences and Neurophysiology, 2021 Objective: The increase in the average life expectancy of humans has resulted in an increased occurrence of late-onset myasthenia gravis (LOMG). It is noticeable that the clinical, immunologic, and prognostic features of patients with LOMG are different ...
Hulya Tireli +2 more
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Pattern recognition receptors and autophagy
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control ...
Ji Eun eOh, Heung Kyu eLee
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