Results 121 to 130 of about 304,930 (167)

Regulation of bovine interleukin-1 receptors

Veterinary Immunology and Immunopathology, 1998
Interleukin-1 is a key player in inflammation and the immune response. The interleukin-1 family consists of three ligands (IL-1 alpha, IL-1 beta, and the IL-1 receptor antagonist) and two receptors (IL-1RI and IL-1RII). Previous studies suggest a dynamic relationship among these receptors and ligands that regulates the magnitude and extent of IL-1 ...
P W, Yu, L A, Schuler, J J, Rejman, H T, Chen, K, Gosink, M, Kehrli, L, Mattocks, B, Nonnecke, C J, Czuprynski   +8 more
openaire   +2 more sources

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Nature, 1990
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
C H, Hannum, C J, Wilcox, W P, Arend, F G, Joslin, D J, Dripps, P L, Heimdal, L G, Armes, A, Sommer, S P, Eisenberg, R C, Thompson   +9 more
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Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991
The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS).
M R, Opp, J M, Krueger
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Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics, 1996
Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
F, Cominelli, T T, Pizarro
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The family of the interleukin‐1 receptors

Immunological Reviews, 2017
SummaryThe extracellular forms of the IL‐1 cytokines are active through binding to specific receptors on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand‐binding receptor chain. For signaling to take place, a non‐binding accessory chain is recruited into a heterotrimeric complex.
Boraschi, D., P. Italiani, S. Weil, M.U. Martin   +4 more
openaire   +3 more sources

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
openaire   +3 more sources

Interleukin-1 receptor antagonism.

Seminars in nephrology, 1997
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of biological effects. The recently identified IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response.
D J, Nikolic-Paterson, H Y, Lan, R C, Atkins   +2 more
openaire   +1 more source

Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus

Immunological Investigations, 1997
Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
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Interleukin-1 and interleukin-1 receptor antagonist.

Nutrition (Burbank, Los Angeles County, Calif.), 1996
Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
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The interleukin-1/interleukin-1-receptor interaction

Annales de l'Institut Pasteur / Immunologie, 1987
H R, MacDonald, J W, Lowenthal
openaire   +2 more sources