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Interleukin-1 receptor antagonist
2000Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruction, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
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Interleukin-1 Receptor/Toll-Like Receptor Signaling
2007Upon stimulation Interleukin-1 receptor (IL-1R), the related IL-18R as well as the Toll-like receptors (TLRs), trigger signaling pathways that activate the transcription factors, nuclear factor κB (NF-κB), activator protein 1 (AP1) and interferon regulatory factor 3 (IRF-3).
Harald Wajant +2 more
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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Cancer Cell, 2022Yared Hailemichael +2 more
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[Interleukin 1 receptor antagonists].
Pediatrie, 1992Interleukin 1 (IL-1) is a polypeptide cytokine produced by various cell types that mediates a broad range of biological activities and possesses a wide spectrum of immunologic and non immunologic properties. Interest has recently focussed on the role of IL-1 as an inflammatory mediator in chronic and acute diseases.
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The interleukin-1 receptor complex and interleukin-1 signal transduction.
European cytokine network, 1997The aim of this mini-review is to give an update on the current developments concerning the IL-1 plasma membrane receptor complex and the modes of signal transduction through the plasma membrane. The mechanisms of signal generation at the cytosolic side of the plasma membrane will be summarized.
M U, Martin, W, Falk
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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
New England Journal of Medicine, 2021Anthony C Gordon +2 more
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Induction of interleukin-1 and interleukin-1 receptor antagonist.
Seminars in oncology, 1997Drugs that affect the production or action, or both, of the pleiotropic inflammatory cytokine interleukin-1 (IL-1) are predicted to have a significant impact on a variety of human diseases. The biochemical properties of IL-1 and the IL-1 receptor antagonist, the mechanism for their production, and the factors that regulate their release are discussed ...
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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis
New England Journal of Medicine, 2021Allan L Klein +2 more
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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Nature Reviews Drug Discovery, 2012Charles A Dinarello +2 more
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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
Nature Reviews Immunology, 2006Thomas A Waldmann
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