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Interleukin-1 Receptor/Toll-Like Receptor Signaling

2007
Upon stimulation Interleukin-1 receptor (IL-1R), the related IL-18R as well as the Toll-like receptors (TLRs), trigger signaling pathways that activate the transcription factors, nuclear factor κB (NF-κB), activator protein 1 (AP1) and interferon regulatory factor 3 (IRF-3).
Harald Wajant   +2 more
openaire   +1 more source

[Interleukin 1 receptor antagonists].

Pediatrie, 1992
Interleukin 1 (IL-1) is a polypeptide cytokine produced by various cell types that mediates a broad range of biological activities and possesses a wide spectrum of immunologic and non immunologic properties. Interest has recently focussed on the role of IL-1 as an inflammatory mediator in chronic and acute diseases.
openaire   +1 more source

Interleukin-1 receptors in mouse brain: characterization and neuronal localization.

Endocrinology, 1990
Toshihiro Takao   +3 more
semanticscholar   +1 more source

The interleukin-1 receptor complex and interleukin-1 signal transduction.

European cytokine network, 1997
The aim of this mini-review is to give an update on the current developments concerning the IL-1 plasma membrane receptor complex and the modes of signal transduction through the plasma membrane. The mechanisms of signal generation at the cytosolic side of the plasma membrane will be summarized.
M U, Martin, W, Falk
openaire   +1 more source

Induction of interleukin-1 and interleukin-1 receptor antagonist.

Seminars in oncology, 1997
Drugs that affect the production or action, or both, of the pleiotropic inflammatory cytokine interleukin-1 (IL-1) are predicted to have a significant impact on a variety of human diseases. The biochemical properties of IL-1 and the IL-1 receptor antagonist, the mechanism for their production, and the factors that regulate their release are discussed ...
openaire   +1 more source

Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

The FASEB Journal, 1996
A.-M. Van Dam   +6 more
semanticscholar   +1 more source

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