Results 51 to 60 of about 304,930 (167)

A New Generation of Treatments for Itch

Acta Dermato-Venereologica, 2020
For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch.
Emilie Fowler, Gil Yosipovitch
doaj   +1 more source

Interleukin 1 , interleukin 1  and interleukin 1 receptor gene polymorphisms in psoriatic arthritis [PDF]

Rheumatology, 2004
Objectives. To investigate polymorphisms of interleukin (IL) 1, IL-1 and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement. Methods. One hundred and forty well-characterized patients with PsA were studied.
openaire   +1 more source

Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer

Acta Pharmaceutica Sinica B
Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathway cascades of interleukin-1 ...
Yifan Feng, Chengjuan Chen, Anqi Shao, Lei Wu, Haiyu Hu, Tiantai Zhang   +5 more
doaj   +1 more source

Regulatory role of IL-1R8 in immunity and disease

Frontiers in Immunology, 2016
Interleukin-1 receptor family members (ILRs) and Toll Like Receptors (TLRs) are characterized by the presence of a conserved intracellular domain, the Toll/IL-1resistance (TIR) domain and are key players in immunity and inflammation.
Martina eMolgora, Isabella eBarajon, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +4 more
doaj   +1 more source

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor family member with regulatory functions in inflammation and immunity

Frontiers in Immunology, 2012
Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation and orientation of the adaptive response.
Federica eRiva, Eduardo eBonavita, Elisa eBarbati, Elisa eBarbati, Marta eMuzio, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +7 more
doaj   +1 more source

Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1

Journal of Bone and Mineral Research, 1993
Abstract Recently, the effects of interleukin-1 (IL-1) on bone resorption in organ culture have been shown to be inhibited by an interleukin-1 receptor antagonist (IL-1RA), a novel monocyte cytokine in the IL-1 family. IL-1RA, which binds to IL-1 receptors and inhibits many of the effects of IL-1α and β, has been purified, cloned, and ...
T A, Guise, I R, Garrett, L F, Bonewald, G R, Mundy   +3 more
openaire   +2 more sources

Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice

BMC Immunology, 2017
Background Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are predicted to have preventive or ...
Cristina Vazquez-Mateo, Justin Collins, Michelle Fleury, Hans Dooms   +3 more
doaj   +1 more source

Targeting neutrophil-driven inflammation in adult-onset still’s disease: molecular insights from gene expression profiles

Arthritis Research & Therapy
Background The rarity and heterogeneity of adult-onset Still’s disease (AOSD) pose significant challenges in understanding its precise pathogenic mechanisms, developing effective treatment options, and establishing therapeutic strategies. A comprehensive
In-Woon Baek, Hyoun-Ah Kim, Kyung-Su Park, Ki-Jo Kim   +3 more
doaj   +1 more source

Interleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist [PDF]

Proceedings of the Nutrition Society, 1994
N. Joseph Espat, Michael A. Rogy, Edward M. Copeland, Lyle L. Moldawer   +3 more
openaire   +1 more source

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

Journal of Lipid Research, 1991
Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove, C Mazzucco, N Allegretto, PA Kiener, G Spitalny, SF Radka, M Shoyab, M Antonaccio, GA Warr   +8 more
doaj   +1 more source