Results 81 to 90 of about 479,777 (310)

JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

Molecular Pain, 2012
Background Proopiomelanocortin (POMC)-derived beta-endorphin1-31 from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment ...
Busch-Dienstfertig Melanie, Labuz Dominika, Wolfram Theresa, Vogel Nicole N, Stein Christoph   +4 more
doaj   +1 more source

Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]

, 2015
The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Simvastatin and Recombinant Antagonist of Receptors of Interleukin-1 Modulate Toll-like Receptors in Experimental Acute Ileitis in Rat

Research in Molecular Medicine, 2014
Background: The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that Toll-like receptors represent key mediators of innate host defense in the intestine, and they are involved in ...
Aleksandr Zherebiatiev, Aleksandr Kamyshnyi   +1 more
doaj  

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor family member with regulatory functions in inflammation and immunity

Frontiers in Immunology, 2012
Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation and orientation of the adaptive response.
Federica eRiva, Eduardo eBonavita, Elisa eBarbati, Elisa eBarbati, Marta eMuzio, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +7 more
doaj   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Regulatory role of IL-1R8 in immunity and disease

Frontiers in Immunology, 2016
Interleukin-1 receptor family members (ILRs) and Toll Like Receptors (TLRs) are characterized by the presence of a conserved intracellular domain, the Toll/IL-1resistance (TIR) domain and are key players in immunity and inflammation.
Martina eMolgora, Isabella eBarajon, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +4 more
doaj   +1 more source

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma, Nimmo, Myra, Robson-Ansley, Paula, Stevenson, Emma, Walshe, Ian   +4 more
core  

Modulation of Functional Activities of Chicken Heterophils by Recombinant Chicken IFN-γ [PDF]

, 2001
The objective of the present studies was to examine the in vitro effects of recombinant chicken interferon-γ (rChIFN-γ) on shape change, phagocytosis, and the oxidative/nonoxidative killing activities of day-old chicken heterophils.
B. Kaspers, E.J. Pishko, HARMON B.G., K.C. Weining, KLEIN J.B., KOGUT M.H., KOGUT M.H., LEINO L., M.H. Kogut, MERRILL G.A., SETO F., STICKLE J.F., WEINING K.C.   +12 more
core   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source