Results 41 to 50 of about 10,848,813 (305)

Bispecific antibodies tethering innate receptors induce human tolerant-dendritic cells and regulatory T cells

Frontiers in Immunology
There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations.
Lucille Lamendour, Mäelle Gilotin, Nora Deluce-Kakwata Nkor, Zineb Lakhrif, Daniel Meley, Anne Poupon, Anne Poupon, Thibaut Laboute, Anne di Tommaso, Jean-Jacques Pin, Denis Mulleman, Denis Mulleman, Guillaume Le Mélédo, Guillaume Le Mélédo, Nicolas Aubrey, Hervé Watier, Florence Velge-Roussel   +16 more
doaj   +1 more source

The effect of lipopolysaccharide on the expression level of immunomodulatory and immunostimulatory factors of human amniotic epithelial cells

BMC Research Notes, 2018
Objective Human amniotic epithelial cells (hAECs) are a novel source of stem cells and have immunomodulatory effects on both the innate and adoptive immune system.
Ramezan Ali Taheri, Hossein Motedayyen, Somayeh Ghotloo, Mohsen Masjedi, Nariman Mosaffa, Abbas Mirshafiey, Mahmood Saffari   +6 more
doaj   +1 more source

Toll-Like Receptors 2, 4, and 7, Interferon-Gamma, Interleukin 10, and Programmed Death Ligand 1 Transcripts in Leishmanin Skin Test-Positive Reactions of Ibizan Hound Dogs

Journal of Immunology Research, 2020
The leishmanin skin test (LST) is an in vivo technique commonly used to evaluate the Leishmania-specific cellular immune response in dogs. However, information regarding the local immune response in LST-positive reactions is scarce.
Laura Ordeix, Sara Montserrat-Sangrà, Pamela Martínez-Orellana, Laia Solano-Gallego   +3 more
doaj   +1 more source

Polymorphisms of interleukin-10 and its receptor and lung function in COPD [PDF]

European Respiratory Journal, 2007
Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the α subunit of its receptor (IL10RA) are ...
J-Q, He, K, Shumansky, X, Zhang, J E, Connett, N R, Anthonisen, A J, Sandford   +5 more
openaire   +2 more sources

γ-aminobutyric acid alleviates LPS-induced acute lung injury in mice through upregulating type B receptors

Archives of Medical Science, 2019
Introduction In recent years, studies have shown that GABA has a certain therapeutic effect on acute lung injury (ALI), but its specific mechanism has not been fully elucidated. The study was designed to investigate the protective effect and mechanism of
Jing Yang, Na Li, Yuanyuan Zheng, Qikun Huang   +3 more
doaj   +1 more source

A model of the ternary complex of interleukin-10 with its soluble receptors [PDF]

BMC Structural Biology, 2005
AbstractBackgroundInterleukin-10 (IL-10) is a cytokine whose main biological function is to suppress the immune response by induction of a signal(s) leading to inhibition of synthesis of a number of cytokines and their cellular receptors. Signal transduction is initiated upon formation of a ternary complex of IL-10 with two of its receptor chains, IL ...
Pletnev, Sergei, Magracheva, Eugenia, Wlodawer, Alexander, Zdanov, Alexander   +3 more
openaire   +2 more sources

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. [PDF]

, 2009
BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has ...
Lapaque Nicolas, Brown Damien P, Buerki, RA, Allen, RL, Brown, DP, Trowsdale John, Allen Rachel L, Jones Des C, Anderson, KJ, Buerki Robin A, Jones, DC, Lapaque, N, Trowsdale, J, Anderson Katie J   +13 more
core   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Oral antibody to interleukin-10 receptor 2, but not interleukin-10 receptor 1, as an effective Eimeria species immunotherapy in broiler chickens

Poultry Science, 2019
Coccidiosis is a major gastrointestinal disease caused by several Eimeria species in floor raised chickens. Feeding an antibody to interleukin 10 (aIL-10) ameliorates the negative symptoms of coccidiosis in broilers, i.e., lack of weight gain, decreased feed conversion, and mortality.
Maria K, Arendt, Laura J, Knoll, Mark E, Cook   +2 more
openaire   +2 more sources

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells

Frontiers in Immunology, 2018
Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental factor that affects the development of RA ...
Da Som Kim, Jeong-Eun Kwon, Seung Hoon Lee, Seung Hoon Lee, Eun Kyung Kim, Jun-Geol Ryu, Kyung-Ah Jung, Jeong-Won Choi, Min-Jung Park, Young-Mee Moon, Sung-Hwan Park, Mi-La Cho, Mi-La Cho, Mi-La Cho, Seung-Ki Kwok   +14 more
doaj   +1 more source