Results 41 to 50 of about 366,691 (317)

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Cellular Physiology and Biochemistry, 2013
Depression is a multicausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has been associated with obesity, diabetes, insulin sensitivity, neuropeptide Y ...
Undine E. Lang, Stefan Borgwardt
doaj   +1 more source

Polymorphisms of interleukin-10 and its receptor and lung function in COPD [PDF]

European Respiratory Journal, 2007
Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the α subunit of its receptor (IL10RA) are ...
J-Q, He, K, Shumansky, X, Zhang, J E, Connett, N R, Anthonisen, A J, Sandford   +5 more
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Bispecific antibodies tethering innate receptors induce human tolerant-dendritic cells and regulatory T cells

Frontiers in Immunology
There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations.
Lucille Lamendour, Mäelle Gilotin, Nora Deluce-Kakwata Nkor, Zineb Lakhrif, Daniel Meley, Anne Poupon, Anne Poupon, Thibaut Laboute, Anne di Tommaso, Jean-Jacques Pin, Denis Mulleman, Denis Mulleman, Guillaume Le Mélédo, Guillaume Le Mélédo, Nicolas Aubrey, Hervé Watier, Florence Velge-Roussel   +16 more
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The effect of lipopolysaccharide on the expression level of immunomodulatory and immunostimulatory factors of human amniotic epithelial cells

BMC Research Notes, 2018
Objective Human amniotic epithelial cells (hAECs) are a novel source of stem cells and have immunomodulatory effects on both the innate and adoptive immune system.
Ramezan Ali Taheri, Hossein Motedayyen, Somayeh Ghotloo, Mohsen Masjedi, Nariman Mosaffa, Abbas Mirshafiey, Mahmood Saffari   +6 more
doaj   +1 more source

Toll-Like Receptors 2, 4, and 7, Interferon-Gamma, Interleukin 10, and Programmed Death Ligand 1 Transcripts in Leishmanin Skin Test-Positive Reactions of Ibizan Hound Dogs

Journal of Immunology Research, 2020
The leishmanin skin test (LST) is an in vivo technique commonly used to evaluate the Leishmania-specific cellular immune response in dogs. However, information regarding the local immune response in LST-positive reactions is scarce.
Laura Ordeix, Sara Montserrat-Sangrà, Pamela Martínez-Orellana, Laia Solano-Gallego   +3 more
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Oral antibody to interleukin-10 receptor 2, but not interleukin-10 receptor 1, as an effective Eimeria species immunotherapy in broiler chickens

Poultry Science, 2019
Coccidiosis is a major gastrointestinal disease caused by several Eimeria species in floor raised chickens. Feeding an antibody to interleukin 10 (aIL-10) ameliorates the negative symptoms of coccidiosis in broilers, i.e., lack of weight gain, decreased feed conversion, and mortality.
Maria K, Arendt, Laura J, Knoll, Mark E, Cook   +2 more
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Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B., Robertson, S.E., Gracie, J.A.   +2 more
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γ-aminobutyric acid alleviates LPS-induced acute lung injury in mice through upregulating type B receptors

Archives of Medical Science, 2019
Introduction In recent years, studies have shown that GABA has a certain therapeutic effect on acute lung injury (ALI), but its specific mechanism has not been fully elucidated. The study was designed to investigate the protective effect and mechanism of
Jing Yang, Na Li, Yuanyuan Zheng, Qikun Huang   +3 more
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Blocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACTHigh doses ofListeria monocytogenesovercome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria.
Silva, RA, Appelberg, R
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Gurney Alison M, Gurney, Alison M.; id_orcid, Alison M Gurney, Kennedy, Charles, Krongkarn Chootip, Charles Kennedy, Gurney, Alison M., Chootip Krongkarn, Kennedy Charles   +9 more
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