Results 21 to 30 of about 10,848,813 (305)

Relevance of Fcγ Receptor and Interleukin‐10 Polymorphisms for Meningococcal Disease [PDF]

The Journal of Infectious Diseases, 2001
The contribution of individual Fcgamma receptor (FcgammaR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcgammaR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcgammaR genotypes ...
van der Pol, W. L., Huizinga, T. W., Vidarsson, G., van der Linden, M. W., Jansen, M. D., Keijsers, V., de Straat, F. G., Westerdaal, N. A., de Winkel, J. G., Westendorp, R. G.   +9 more
openaire   +3 more sources

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]

, 2011
<p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p> <p><b>Methods and Results:</b> In the ...
Jukema, J.W., Trompet, S., Sattar, N., David J. Stott, Jukema, J. Wouter, Heather M. Murray, Ian Ford, Ford, I., Welsh, Paul, Anton J.M. de Craen, McInnes, Iain B., Trompet, Stella, Paul Welsh, J. Wouter Jukema, Westendorp, Rudi G.J., McInnes, I.B., Welsh, P., Westendorp, R.G.J., Packard, C.J., Murray, H.M., Craen, A.J.M. de, de Craen, Anton J.M., Rudi G.J. Westendorp, Sattar, Naveed, Stella Trompet, Stott, David J., Naveed Sattar, Ford, Ian, Chris J. Packard, Murray, Heather M., PROSPER Study Grp, Packard, Chris J., Iain B. McInnes, Stott, D.J.   +33 more
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Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular immune responses to protect from diseases.In this study, a potential peptide derived from IL-10 based on molecular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
openaire   +3 more sources

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Cells, 2023
Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the transcription factor STAT3.
Kuntzel, Thomas, Spenlé, Caroline, Pham-Van, Lucas, Birmpili, Dafni, Riou, Aurélien, Loeuillet, Aurore, Charmarke-Askar, Imane, Bagnard, Dominique   +7 more
openaire   +3 more sources

Alexithymia and interleukin variations in somatoform disorder [PDF]

, 2007
Objective: The aim of the present study was to investigate if somatoform disorders (SFD) are associated with changes in the normal serum levels of important interleukins, and further, to establish if these changes are related to the presence and severity
Schwarz, M.J., Ridout, Nathan, Schwarz, Markus J., Pedrosa Gil, F., Schoechlin, Claudia, Nickel, Marius, Schmidmaier, R., Gil, Francisco Pedrosa, Ridout, N., Schmidmaier, Ralf, Nickel, M., Schoechlin, C.   +11 more
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Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain [PDF]

Molecular and Cellular Biology, 1995
The functions of wild-type and mutant mouse interleukin-10 receptors (mIL-10R) expressed in murine Ba/F3 cells were studied. As observed previously, IL-10 stimulates proliferation of IL-10R-expressing Ba/F3 cells. Accumulation of viable cells in the proliferation assay is to a significant extent balanced by concomitant cell death.
A S, Ho, S H, Wei, A L, Mui, A, Miyajima, K W, Moore   +4 more
openaire   +2 more sources

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor [PDF]

New England Journal of Medicine, 2009
The molecular cause of inflammatory bowel disease is largely unknown.We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease.
Erik-Oliver, Glocker, Daniel, Kotlarz, Kaan, Boztug, E Michael, Gertz, Alejandro A, Schäffer, Fatih, Noyan, Mario, Perro, Jana, Diestelhorst, Anna, Allroth, Dhaarini, Murugan, Nadine, Hätscher, Dietmar, Pfeifer, Karl-Walter, Sykora, Martin, Sauer, Hans, Kreipe, Martin, Lacher, Rainer, Nustede, Cristina, Woellner, Ulrich, Baumann, Ulrich, Salzer, Sibylle, Koletzko, Neil, Shah, Anthony W, Segal, Axel, Sauerbrey, Stephan, Buderus, Scott B, Snapper, Bodo, Grimbacher, Christoph, Klein   +27 more
openaire   +3 more sources

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]

, 2012
Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Stefan Zeuzem, Herrmann, Eva, Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Rudloff, Ina, Bernd Kronenberger, Waidmann, Oliver, Albrecht Piiper, Pfeilschifter, Josef (Prof. Dr.), Piiper, Albrecht, Heiko Mühl, Filmann, Natalie, Ina Rudloff, Malte Bachmann, Eva Herrmann, Josef Pfeilschifter, Lisa Kapper, Bachmann, Malte, Brunner, Friederike, Kapper, Lisa, Mühl, Heiko, Natalie Filmann, Zeuzem, Stefan   +23 more
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Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +1 more source