Results 31 to 40 of about 81,009,517 (308)

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular immune responses to protect from diseases.In this study, a potential peptide derived from IL-10 based on molecular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
openaire   +3 more sources

Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice

Neurobiology of Stress, 2019
The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility.
Joshua McWhirt, Monica Sathyanesan, Dayalan Sampath, Samuel S. Newton   +3 more
doaj   +1 more source

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor [PDF]

New England Journal of Medicine, 2009
The molecular cause of inflammatory bowel disease is largely unknown.We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease.
Erik-Oliver, Glocker, Daniel, Kotlarz, Kaan, Boztug, E Michael, Gertz, Alejandro A, Schäffer, Fatih, Noyan, Mario, Perro, Jana, Diestelhorst, Anna, Allroth, Dhaarini, Murugan, Nadine, Hätscher, Dietmar, Pfeifer, Karl-Walter, Sykora, Martin, Sauer, Hans, Kreipe, Martin, Lacher, Rainer, Nustede, Cristina, Woellner, Ulrich, Baumann, Ulrich, Salzer, Sibylle, Koletzko, Neil, Shah, Anthony W, Segal, Axel, Sauerbrey, Stephan, Buderus, Scott B, Snapper, Bodo, Grimbacher, Christoph, Klein   +27 more
openaire   +3 more sources

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Cells, 2023
Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the transcription factor STAT3.
Kuntzel, Thomas, Spenlé, Caroline, Pham-Van, Lucas, Birmpili, Dafni, Riou, Aurélien, Loeuillet, Aurore, Charmarke-Askar, Imane, Bagnard, Dominique   +7 more
openaire   +3 more sources

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +1 more source

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Kennedy, Charles, Gurney, Alison M.   +2 more
core   +5 more sources

Nicotinamide inhibits melanoma in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2020
Background Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the amide form of Niacin, was ...
Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano, Antonio Facchiano   +8 more
doaj   +1 more source

Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain [PDF]

Molecular and Cellular Biology, 1995
The functions of wild-type and mutant mouse interleukin-10 receptors (mIL-10R) expressed in murine Ba/F3 cells were studied. As observed previously, IL-10 stimulates proliferation of IL-10R-expressing Ba/F3 cells. Accumulation of viable cells in the proliferation assay is to a significant extent balanced by concomitant cell death.
A S, Ho, S H, Wei, A L, Mui, A, Miyajima, K W, Moore   +4 more
openaire   +2 more sources

Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling

Frontiers in Immunology, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Andreas Körner, David Köhler, Mariella Schneider, Judith M. Roth, Tiago F. Granja, Claudia Eggstein, Valbona Mirakaj, Peter Rosenberger   +7 more
doaj   +1 more source

Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor [PDF]

Journal of Biological Chemistry, 1995
The extracellular region of the human interleukin-10 (hIL-10) receptor was expressed using a myeloma cell line and was purified to homogeneity by ligand-affinity chromatography. SDS-polyacrylamide gel electrophoresis analysis indicated that the soluble receptor is glycosylated and has an apparent molecular mass of 35,000-45,000. Under native conditions,
J C, Tan, S, Braun, H, Rong, R, DiGiacomo, E, Dolphin, S, Baldwin, S K, Narula, P J, Zavodny, C C, Chou   +8 more
openaire   +2 more sources