Results 11 to 20 of about 495,989 (311)

Interleukin 10 and interleukin 10 receptor in paediatric inflammatory bowel disease: from bench to bedside lesson [PDF]

Journal of Inflammation, 2021
Abstract Background The differences between adults and children in inflammatory bowel disease (IBD) phenotype, severity, complications, co-morbidities, and response to the therapy resulted in the extraction of paediatric IBD.
Paulina Krawiec, Agnieszka Pawłowska-Kamieniak, Elżbieta Pac-Kożuchowska   +2 more
openaire   +3 more sources

Mapping of the interleukin‐10/interleukin‐10 receptor combining site [PDF]

Protein Science, 1998
AbstractThe discontinuous interleukin‐10(IL‐10)/interleukin‐10 receptor (IL‐10R) combining site was mapped using sets of overlapping peptides derived from both binding partners bound to continuous cellulose membranes. Low affinity binding of single regions of the discontinuous contact sites on IL‐10 and IL‐10R could be identified due to (1) high ...
U, Reineke, R, Sabat, H D, Volk, J, Schneider-Mergener   +3 more
openaire   +2 more sources

Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk [PDF]

Genes & Immunity, 2006
Interactions between environment and immune system play an essential role in the aetiology of immunopathologies, including lymphomas. Toll-like receptors (TLR) belong to a group of pattern recognition receptors, with importance for innate immune response and inflammatory processes.
A, Nieters, L, Beckmann, E, Deeg, N, Becker   +3 more
openaire   +2 more sources

A receptor for interleukin 10 is related to interferon receptors. [PDF]

Proceedings of the National Academy of Sciences, 1993
We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically.
A S, Ho, Y, Liu, T A, Khan, D H, Hsu, J F, Bazan, K W, Moore   +5 more
openaire   +2 more sources

The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor [PDF]

The Journal of Experimental Medicine, 1998
The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4,
Spencer, S.D., Di Marco, F., Hooley, J., Pitts-Meek, S., Bauer, M., Ryan, A.M., Sordat, B., Gibbs, V.C., Aguet, M.   +8 more
openaire   +3 more sources

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular immune responses to protect from diseases.In this study, a potential peptide derived from IL-10 based on molecular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
openaire   +3 more sources

Relevance of Fcγ Receptor and Interleukin‐10 Polymorphisms for Meningococcal Disease [PDF]

The Journal of Infectious Diseases, 2001
The contribution of individual Fcgamma receptor (FcgammaR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcgammaR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcgammaR genotypes ...
van der Pol, W. L., Huizinga, T. W., Vidarsson, G., van der Linden, M. W., Jansen, M. D., Keijsers, V., de Straat, F. G., Westerdaal, N. A., de Winkel, J. G., Westendorp, R. G.   +9 more
openaire   +3 more sources

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Cells, 2023
Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the transcription factor STAT3.
Thomas Kuntzel, Caroline Spenlé, Lucas Pham-Van, Dafni Birmpili, Aurélien Riou, Aurore Loeuillet, Imane Charmarke-Askar, Dominique Bagnard   +7 more
openaire   +3 more sources

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor [PDF]

New England Journal of Medicine, 2009
The molecular cause of inflammatory bowel disease is largely unknown.We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease.
Erik-Oliver, Glocker, Daniel, Kotlarz, Kaan, Boztug, E Michael, Gertz, Alejandro A, Schäffer, Fatih, Noyan, Mario, Perro, Jana, Diestelhorst, Anna, Allroth, Dhaarini, Murugan, Nadine, Hätscher, Dietmar, Pfeifer, Karl-Walter, Sykora, Martin, Sauer, Hans, Kreipe, Martin, Lacher, Rainer, Nustede, Cristina, Woellner, Ulrich, Baumann, Ulrich, Salzer, Sibylle, Koletzko, Neil, Shah, Anthony W, Segal, Axel, Sauerbrey, Stephan, Buderus, Scott B, Snapper, Bodo, Grimbacher, Christoph, Klein   +27 more
openaire   +3 more sources

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source