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Transcriptional regulation of the human interleukin-12 receptor beta2 gene

, 2002
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Interleukin 12 (IL12B) and Interleukin 12 Receptor (IL12RB1) Gene Polymorphisms in Rheumatoid Arthritis

Human Immunology, 2005
The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3'
Orozco, Gisela, González-Gay, Miguel A., Paco, Laura, López-Nevot, Miguel A., Guzmán, Manuel, Pascual-Salcedo, Dora, Balsa, Alejandro, Martín, Javier   +7 more
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THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

Annual Review of Immunology, 1998
▪ Abstract  Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its activities are mediated through a high-affinity receptor composed of two subunits, designated β1 and β2.
M K, Gately, L M, Renzetti, J, Magram, A S, Stern, L, Adorini, U, Gubler, D H, Presky   +6 more
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Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

European Journal of Immunology, 1999
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-bonded subunits, p35 and p40, which has important regulatory effects on T cells and natural killer (NK) cells. In contrast to heterodimeric IL-12, a homodimer of the p40 subunit, designated (p40)2, has been shown to be a potent IL-12 antagonist.
X, Wang, V L, Wilkinson, F J, Podlaski, C, Wu, A S, Stern, D H, Presky, J, Magram   +6 more
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Influence of interleukin-12 receptor β1 polymorphisms on tuberculosis

Human Genetics, 2002
Host genetic factors may be important determinants of susceptibility to tuberculosis, and several candidate gene polymorphisms have been shown to date. A series of recent reports concerning rare human deficiencies in the type-1 cytokine pathway suggest that more subtle variants of relevant genes may also contribute to susceptibility to tuberculosis at ...
Mitsuteru, Akahoshi, Hitoshi, Nakashima, Katsuhisa, Miyake, Yasushi, Inoue, Sakiko, Shimizu, Yosuke, Tanaka, Kaoru, Okada, Takeshi, Otsuka, Mine, Harada   +8 more
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Genetic evidence for the existence of interleukin-23 and for variation in the interleukin-12 and interleukin-12 receptor genes in the horse

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2006
Immune loci, characterized by features reflecting their role in defense reactions and consequently related to evolutionary mechanisms, including polymorphisms or association with disease are suitable candidates for comparative analysis. Interleukin-12 and related cytokines are key molecules regulating natural and specific immune responses.
Petr, Kralik, Jan, Matiasovic, Petr, Horin   +2 more
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