Results 281 to 290 of about 478,975 (311)
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A CASE OF INTERLEUKIN-12 RECEPTOR β-1 DEFICIENCY WITH RECURRENT LEISHMANIASIS
Pediatric Infectious Disease Journal, 2007Interleukin-12 receptor beta-1 (IL-12Rbeta1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The
Ozden, Sanal +7 more
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Biological function and distribution of human interleukin‐12 receptor β chain
European Journal of Immunology, 1996AbstractWe previously described the cloning of a cDNA encoding an interleukin‐12 receptor (IL‐12R) subunit, designated β, that bound IL‐12 with low affinity when expressed in COS cells. We now report that a pair of monoclonal antibodies (mAb), 2B10 and 2.4E6, directed against different epitopes on the IL‐12Rβ chain, when used in combination, strongly ...
C Y, Wu +10 more
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Blood, 2000
Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are likely mediated by its ability to enhance the cytotoxic activity of NK cells and cytotoxic T lymphocytes, and to induce the production of interferon (IFN)-γ by NK and T ...
K S, Wang, D A, Frank, J, Ritz
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Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are likely mediated by its ability to enhance the cytotoxic activity of NK cells and cytotoxic T lymphocytes, and to induce the production of interferon (IFN)-γ by NK and T ...
K S, Wang, D A, Frank, J, Ritz
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Molecular Biology of lnterleukin‐12 Receptors
Annals of the New York Academy of Sciences, 1996IL-12 receptors are expressed primarily on activated T and NK cells. Using labeled IL-12, three classes of IL-12-binding sites have been identified on human PHA-activated lymphoblasts. Their Kd values are 5-20 pM (high affinity), 50-200 pM (intermediate affinity), and 2-6 nM (low affinity).
U, Gubler, D H, Presky
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Cutaneous leukocytoclastic vasculitis in a child with interleukin-12 receptor beta-1 deficiency
The Journal of Pediatrics, 2006We report a patient with complete interleukin-12 receptor beta-1 deficiency associated with cutaneous leukocytoclastic vasculitis. The patient experienced Bacille Calmette Guérin, Mycobacterium chelonae, and Salmonella enteritidis infection. Vasculitis affecting both small arteries and postcapillary venules due to deposition of immune complexes was ...
Kutukculer, N +7 more
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Molecular cloning of interleukin-12 receptor β2 chain and its expression in dogs
Veterinary Immunology and Immunopathology, 2005This study cloned canine interleukin-12 receptor beta2 (IL-12Rbeta2). Its nucleotide sequences were determined. Canine IL-12Rbeta2 showed 85.4% homology at the nucleotide level and 76.8% homology at the amino acid level with human IL-12Rbeta2. Its structural motifs were well conserved.
Eri, Kitamiya +2 more
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Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans
Respiration, 2005<i>Background:</i> The fact that only 10% of people infected with <i>Mycobacterium tuberculosis</i> develop clinical tuberculosis (TB) suggests the presence of genetic factors in the pathogenesis of TB. To date, a number of single nucleotide polymorphisms (SNPs) in several candidate genes have been proposed as genetic risk ...
Hye Won, Lee +6 more
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Interleukin-22: Immunobiology and Pathology
Annual Review of Immunology, 2015Jarrod A Dudakov +2 more
exaly
Historical overview of the interleukin-6 family cytokine
Journal of Experimental Medicine, 2020Sujin Kang +2 more
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