Results 61 to 70 of about 478,975 (311)
The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]
, 2010 The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma +4 more
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The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]
, 2016 Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Neural Regeneration Research[INLINE:1] Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system. Macrophage polarization plays an important role in the pathogenesis of experimental
Chunyun Liu +7 more
doaj +1 more source
FEBS Letters, 2007 Interleukin 12 receptor β1 (IL‐12Rβ1) and β2 (IL‐12Rβ2) constitute the functional and high‐affinity receptor complex for interleukin 12 (IL‐12) and mediate important functions in activated T cells. In this study, we identified cyclin G associated kinase (GAK) as a new IL‐12Rβ2‐interacting protein using yeast two‐hybrid system and confirmed it by ...
Lin, Ying +6 more
openaire +3 more sources
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Interleukin-35 in autoimmune dermatoses: Current concepts
Open Medicine, 2022 Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming +3 more
doaj +1 more source
The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]
, 2007 CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris +6 more
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Natural killer cells as an initial defense against pathogens. [PDF]
, 2006 Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
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