Results 11 to 20 of about 446,676 (208)

Novel Biological Therapies for Severe Asthma Endotypes

Biomedicines, 2022
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini, Alessandro Vatrella   +8 more
doaj   +1 more source

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]

, 1998
Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao, Simon, Melvin I., Wu, Dianqing, Xie, Wei, Yuan, Huidong   +4 more
core   +1 more source

Polymorphisms in Interleukin 13 Signaling and Interacting Genes Predict Advanced Fibrosis and Hepatocellular Carcinoma Development in Non-Alcoholic Steatohepatitis

Biology, 2020
Background: non-alcoholic steatohepatitis (NASH) recently headlined hepatocellular carcinoma (HCC) worldwide. This study aims to unveil the role of some unaddressed critical players that might aid in understanding, predicting, and targeting NASH and NASH-
Marwa O. El-Derany
doaj   +1 more source

Kinetic Analysis of the Interleukin-13 Receptor Complex [PDF]

Journal of Biological Chemistry, 2002
Interleukin (IL)-13 is a key cytokine associated with the asthmatic phenotype. It signals via its cognate receptor, a complex of IL-13 receptor alpha1 chain (IL-13Ralpha1) with IL-4Ralpha; however, a second protein, IL-13Ralpha2, also binds IL-13. To determine the binding contributions of the individual components of the IL-13 receptor to IL-13, we ...
Andrews, Allison-Lynn, Holloway, John W., Puddicombe, Sarah M., Holgate, Stephen T., Davies, Donna E.   +4 more
openaire   +3 more sources

In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand

Molecular Therapy: Methods & Clinical Development, 2021
Despite their exceptional capacity for transgene delivery ex vivo, lentiviral (LV) vectors have been slow to demonstrate clinical utility in the context of in vivo applications.
Takele Argaw, Michael P. Marino, Andrew Timmons, Lindsey Eldridge, Kazuyo Takeda, Pingjuan Li, Anna Kwilas, Wu Ou, Jakob Reiser   +8 more
doaj   +1 more source

Development and characterization of monoclonal antibodies specific for chicken interleukin-13 and their neutralizing effects in chicken primary monocytes

Poultry Science, 2020
Compared with mammals, the functionality of chicken cytokines is not well understood because of the unavailability of immune reagents. Mammalian interleukin (IL)-13 is an important Th2 type cytokine with well-known biological functions through its 2 ...
Atul A. Chaudhari, Woo H. Kim, Hyun S. Lillehoj   +2 more
doaj   +1 more source

The evolution of IL-4 and IL-13 and their receptor subunits [PDF]

, 2015
Peer ...
Secombes, Christopher J., Wang, Tiehui
core   +1 more source

Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

eLife, 2012
Toll-like receptors (TLRs) detect microbial infections and trigger innate immune responses. Among vertebrate TLRs, the role of TLR13 and its ligand are unknown. Here we show that TLR13 detects the 23S ribosomal RNA of both gram-positive and gram-negative
Xiao-Dong Li, Zhijian J Chen
doaj   +1 more source

Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. [PDF]

PLoS ONE, 2012
Airway epithelial cells play a central role in the physiopathology of asthma. They release eotaxins when treated with T(H)2 cytokines such as interleukin (IL)-4 or IL-13, and these chemokines attract eosinophils and potentiate the biosynthesis of ...
Véronique Provost, Anick Langlois, François Chouinard, Marek Rola-Pleszczynski, Jamila Chakir, Nicolas Flamand, Michel Laviolette   +6 more
doaj   +1 more source

Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching

Frontiers in Immunology, 2023
BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis.
Masataka Suehiro, Tomofumi Numata, Ryo Saito, Nozomi Yanagida, Chie Ishikawa, Kazue Uchida, Tomoko Kawaguchi, Yuhki Yanase, Yozo Ishiuji, John McGrath, Akio Tanaka   +10 more
doaj   +1 more source