Results 21 to 30 of about 268,441 (265)
New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors. [PDF]
PLoS ONE, 2013 Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous astrocytomas in dogs resemble human disease and have been proposed as translational model system
Waldemar Debinski +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Histamine (HA) is a potent mediator that plays a central role in inflammation and allergy, acting through four G-protein-coupled receptors (i.e. H1–H4). HA is an accepted promoter of type 2 immunity in CD4+ T cells during hypersensitivity. Previously, we
Julieta Alcain +7 more
doaj +1 more source
Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model. [PDF]
PLoS ONE, 2016 The need for new options for chronic lung diseases promotes the research on stem cells for lung repair. Bone marrow-derived mesenchymal stem cells (MSCs) can modulate lung inflammation, but the data on cellular processes involved in early airway ...
Konrad Urbanek +11 more
doaj +1 more source
Basophils in pruritic skin diseases
Frontiers in Immunology, 2023 Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and ...
Daniela Wiebe +6 more
doaj +1 more source
The role of IL-13 gene polymorphism in the exacerbation of Asthma severity
Sokoto Journal of Medical Laboratory Science, 2023 Asthma is a chronic airway inflammatory disorder characterized by persistent airway inflammation, obstruction, and hyper-responsiveness. The role of cytokines, particularly Interleukin-13 (IL-13), in the pathogenesis of asthma has been extensively ...
Kabir, I.M.1, Ibrahim, S.2, Badamasi, I. M.3, Ibrahim H.S.4, Bala J.A.1, Aliyu I.A1*.
doaj
Physiological Reports, 2019 Background The immune system generates inflammatory responses through cytokines like Interleukin 6 (IL‐6) and the Tumor Necrosis Factor alpha (TNF α); these cytokines mediate cellular responses aided by the presence of soluble receptors such as: Soluble ...
Henry H. León‐Ariza +3 more
doaj +1 more source
Immune regulation in pathophysiology and targeted therapy for itch in atopic dermatitis
Dermatologica Sinica, 2016 Itch is an unpleasant perception that provokes one to desire to scratch. It results from the activation of free nerve endings by noxious stimuli in the skin.
Chih-Hung Lee
doaj +1 more source
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity. [PDF]
PLoS ONE, 2013 With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8(+) T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g.
Danushka K Wijesundara +3 more
doaj +1 more source
Interleukin-13 Receptor Alpha 2-Targeted Glioblastoma Immunotherapy [PDF]
BioMed Research International, 2014 Glioblastoma (GBM) is the most lethal primary brain tumor, and despite several refinements in its multimodal management, generally has very poor prognosis. Targeted immunotherapy is an emerging field of research that shows great promise in the treatment of GBM.
Sadhak Sengupta +3 more
openaire +2 more sources
Allergy MedicineAtopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. It usually develops in childhood and may persist into adulthood. Dupilumab is a fully human monoclonal antibody directed against interleukin-4R-alpha, the common chain ...
Jing Zhang +4 more
doaj +1 more source