Results 31 to 40 of about 268,441 (265)

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13

Brazilian Journal of Infectious Diseases, 2010
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B. Coêlho, Maria Jania Teixeira, Erika Freitas Mota, Mércia Sindeaux Frutuoso, João Santana da Silva, Aldina Barral, Manoel Barral-Netto, Margarida Maria L. Pompeu   +7 more
doaj   +1 more source

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell Reports, 2014
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia ...
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez   +18 more
doaj   +1 more source

IL-13Rα2 is a Glioma-Restricted Receptor for Interleukin-13

Neoplasia, 2002
We have found that binding sites for interleukin-13 (IL-13) are overexpressed in a vast majority of high-grade astrocytomas (HGAs). These binding sites for IL-13 are distinct from the physiological receptor in that it does not bind IL-4. We also demonstrated that IL-13 receptor alpha 2 protein chain (IL-13Ralpha2), an IL-4-independent receptor for IL ...
Akiva Mintz, Denise M. Gibo, Becky Slagle-Webb, Neil D. Christensent, Waldemar Debinski   +4 more
openaire   +3 more sources

Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review

Dermatology and Therapy, 2023
For decades, topical corticosteroids have been the mainstay of treatment for mild-to-moderate inflammatory skin diseases, even though only short-term use is approved for these agents and systemic inflammation is not addressed.
Andrew Blauvelt, Richard G. Langley, Kenneth B. Gordon, Jonathan I. Silverberg, Kilian Eyerich, Morten O. A. Sommer, Jakob Felding, Richard B. Warren   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Serum levels of interleukin-2 in cancer patients: Preliminary considerations

The International Journal of Biological Markers, 1989
In order to investigate the production of interleukin-2 (IL-2) in human neoplasms, we determined IL-2 and soluble IL-2 receptors (sIL-2R) in serum from 18 patients with lymphoma and 28 patients with solid tumors, with (15 cases) or without (13 cases ...
P. Lissoni, S. Viviani, A. Santoro, S. Barni, G. Tancini   +4 more
doaj   +1 more source

Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2

Cell Reports, 2013
Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic disorders.
Chuan Hua He, Chun Geun Lee, Charles S. Dela Cruz, Chang-Min Lee, Yang Zhou, Farida Ahangari, Bing Ma, Erica L. Herzog, Stephen A. Rosenberg, Yue Li, Adel M. Nour, Chirag R. Parikh, Insa Schmidt, Yorgo Modis, Lloyd Cantley, Jack A. Elias   +15 more
doaj   +1 more source

Interleukin-13 and its receptors in colorectal cancer (Review)

Biomedical Reports, 2013
Interleukin (IL)-13 is an immunoregulatory cytokine secreted by numerous immune cells. Its functions are similar to those of IL-4 and they share a common receptor. This cytokine has been included in recent studies on human tumors and malignant diseases, evoking a scientific interest to investigate the role of IL-13 and its receptors as novel biomarkers
Ru, Zhou, Shiguang, Qian, Xiaodong, Gu, Zongyou, Chen, Jianbin, Xiang   +4 more
openaire   +3 more sources

Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma [PDF]

International Archives of Allergy and Immunology, 2010
<i>Background:</i> Asthma and rhinitis may represent two manifestations of the same airway disease. Genetic research can increase our understanding of their common or distinct pathogenesis. <i>IL13</i> and <i>IL4R</i> polymorphisms are associated with asthma and show gene-gene interaction in asthma.
Bottema, Renske W. B., Nolte, Ilja M., Howard, Timothy D., Koppelman, Gerard H., Dubois, Anthony E. J., de Meer, Gea, Kerkhof, Marjan, Bleecker, Eugene R., Meyers, Deborah A., Postma, Dirkje S.   +9 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source