Results 11 to 20 of about 268,441 (265)

Polymorphisms in Interleukin 13 Signaling and Interacting Genes Predict Advanced Fibrosis and Hepatocellular Carcinoma Development in Non-Alcoholic Steatohepatitis

Biology, 2020
Background: non-alcoholic steatohepatitis (NASH) recently headlined hepatocellular carcinoma (HCC) worldwide. This study aims to unveil the role of some unaddressed critical players that might aid in understanding, predicting, and targeting NASH and NASH-
Marwa O. El-Derany
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In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand

Molecular Therapy: Methods & Clinical Development, 2021
Despite their exceptional capacity for transgene delivery ex vivo, lentiviral (LV) vectors have been slow to demonstrate clinical utility in the context of in vivo applications.
Takele Argaw, Michael P. Marino, Andrew Timmons, Lindsey Eldridge, Kazuyo Takeda, Pingjuan Li, Anna Kwilas, Wu Ou, Jakob Reiser   +8 more
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Development and characterization of monoclonal antibodies specific for chicken interleukin-13 and their neutralizing effects in chicken primary monocytes

Poultry Science, 2020
Compared with mammals, the functionality of chicken cytokines is not well understood because of the unavailability of immune reagents. Mammalian interleukin (IL)-13 is an important Th2 type cytokine with well-known biological functions through its 2 ...
Atul A. Chaudhari, Woo H. Kim, Hyun S. Lillehoj   +2 more
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Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

eLife, 2012
Toll-like receptors (TLRs) detect microbial infections and trigger innate immune responses. Among vertebrate TLRs, the role of TLR13 and its ligand are unknown. Here we show that TLR13 detects the 23S ribosomal RNA of both gram-positive and gram-negative
Xiao-Dong Li, Zhijian J Chen
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Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. [PDF]

PLoS ONE, 2012
Airway epithelial cells play a central role in the physiopathology of asthma. They release eotaxins when treated with T(H)2 cytokines such as interleukin (IL)-4 or IL-13, and these chemokines attract eosinophils and potentiate the biosynthesis of ...
Véronique Provost, Anick Langlois, François Chouinard, Marek Rola-Pleszczynski, Jamila Chakir, Nicolas Flamand, Michel Laviolette   +6 more
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Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-α [PDF]

Journal of Biological Chemistry, 1999
Interleukin (IL)-13 and IL-4 are pleiotropic immunoregulatory cytokines that share many overlapping biological properties reflecting the fact that both can utilize a receptor complex composed of the IL-4 receptor-alpha (IL-4Ralpha) chain and the IL-13Ralpha chain.
P L, Orchansky, R, Kwan, F, Lee, J W, Schrader   +3 more
openaire   +2 more sources

Chromosome mapping and expression of the human interleukin-13 receptor

Immunology Letters, 1997
Interleukin-13 (IL-13) is a cytokine secreted by activated T cells and shares most but not all biological activities with interleukin-4 (IL-4). Both cytokines play an important role as a switch factor directing synthesis of IgE; they act on monocytes and endothelial cells, but unlike IL-4, IL-13 does not act on T cells. These cytokines have both common
J, Guo, F, Apiou, M P, Mellerin, B, Lebeau, Y, Jacques, S, Minvielle   +5 more
openaire   +3 more sources

Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching

Frontiers in Immunology, 2023
BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis.
Masataka Suehiro, Tomofumi Numata, Ryo Saito, Nozomi Yanagida, Chie Ishikawa, Kazue Uchida, Tomoko Kawaguchi, Yuhki Yanase, Yozo Ishiuji, John McGrath, Akio Tanaka   +10 more
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The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis

Mediators of Inflammation, 2017
The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by ...
Bunsoon Choi, Chang-Hee Suh, Hyoun-Ah Kim, Hasan M. Sayeed, Seonghyang Sohn   +4 more
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Inflammation and cell-to-cell communication, two related aspects in frailty

Immunity & Ageing, 2022
Background Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life.
Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita, Cristina Cereda   +5 more
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