Results 51 to 60 of about 268,441 (265)

Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

Nature Communications, 2023
AbstractImmune system molecules are expressed by neurons, yet their functions are often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR subunits and, in turn, increases synaptic activity and CREB-mediated ...
Shun Li, Florian olde Heuvel, Rida Rehman, Oumayma Aousji, Albrecht Froehlich, Zhenghui Li, Rebecca Jark, Wanhong Zhang, Alison Conquest, Sarah Woelfle, Michael Schoen, Caitlin C. O´Meara, Richard Lee Reinhardt, David Voehringer, Jan Kassubek, Albert Ludolph, Markus Huber-Lang, Bernd Knöll, Maria Cristina Morganti-Kossmann, Marisa M. Brockmann, Tobias Boeckers, Francesco Roselli   +21 more
openaire   +5 more sources

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis

Pharmaceuticals, 2020
Estrogen-related receptors (ERRs) are the first identified orphan nuclear receptors. The ERR family consists of ERRα, ERRβ, and ERRγ, regulating diverse isoform-specific functions.
Yunhui Min, Dahye Kim, Godagama Gamaarachchige Dinesh Suminda, Xiangyu Zhao, Mangeun Kim, Yaping Zhao, Young-Ok Son   +6 more
doaj   +1 more source

The early stage of pregnancy modulates toll-like receptor signaling in the ovine liver

Journal of Applied Animal Research, 2021
Toll-like receptors (TLRs) participate in maternal immune regulation at multiple maternal-fetal interfaces. The liver is crucial for innate and adaptive immunity during pregnancy.
Meihong Gao, Chunjiang Cai, Xu Han, Luyu Wang, Weifeng Zhang, Leying Zhang, Ling Yang   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes [PDF]

Journal of Biological Chemistry, 1998
Human B cells stimulated through both their immunoglobulin and CD40 receptors up-regulate 745 +/- 51 interleukin (IL)-13 ligand binding sites with an affinity of 0.91 +/- 0.08 nM within 24 h. IL-13 binds primarily to the IL-13Ralpha1 with subsequent sequestration of the IL-4Ralpha into the complex.
H, Ogata, D, Ford, N, Kouttab, T C, King, N, Vita, A, Minty, J, Stoeckler, D, Morgan, C, Girasole, J W, Morgan, A L, Maizel   +10 more
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

IL‐19 induced by IL‐13/IL‐17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP‐9 expression via ERK/NF‐κB signaling pathway

Clinical and Translational Allergy, 2021
Background Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is crucial for the pathologic tissue remodeling in CRS ...
Xia Li, Jiancong Huang, Xiaohong Chen, Xiaoping Lai, Zizhen Huang, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang   +8 more
doaj   +1 more source

Significance of interleukin-13 receptor alpha 2-targeted glioblastoma therapy [PDF]

Neuro-Oncology, 2014
Glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors despite surgical and therapeutic advancements. Targeted therapies of neoplastic diseases, including GBM, have received a great deal of interest in recent years. A highly studied target of GBM is interleukin-13 receptor α chain variant 2 (IL13Rα2).
Bart, Thaci, Christine E, Brown, Emanuela, Binello, Katherine, Werbaneth, Prakash, Sampath, Sadhak, Sengupta   +5 more
openaire   +2 more sources