Results 61 to 70 of about 448,959 (307)

IL-4 deficiency is associated with mechanical hypersensitivity in mice. [PDF]

PLoS ONE, 2011
Interleukin-4 (IL-4) is an anti-inflammatory and analgesic cytokine that induces opioid receptor transcription. We investigated IL-4 knockout (ko) mice to characterize their pain behavior before and after chronic constriction injury (CCI) of the sciatic ...
Nurcan Üçeyler, Tengü Topuzoğlu, Peter Schiesser, Saskia Hahnenkamp, Claudia Sommer   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The barrier-protective effect of β-eudesmol against type 2-inflammatory cytokine-induced tight junction disassembly in airway epithelial cells.

PLoS ONE
Allergic inflammation, which is the pathogenesis of allergic rhinitis and asthma, is associated with disruption of the airway epithelial barrier due to the effects of type 2 inflammatory cytokines, i.e. interleukin-4 and interleukin-13 (IL-4/13).
Phuntila Tharabenjasin, Aekkacha Moonwiriyakit, Jenjira Sontikun, Kanokphorn Timpratueang, Suhaibee Kuno, Thitinan Aiebchun, Nathjanan Jongkon, Rungrawee Mongkolrob, Noel Pabalan, Kiattawee Choowongkomon, Chatchai Muanprasat   +10 more
doaj   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris, Gu, Mei, Lehnert, Hendrik, Markovic, Danijela, Newton, Rob, Slater, Donna, Vatish, Manu   +6 more
core   +1 more source

MicroRNA-143 Downregulates Interleukin-13 Receptor Alpha1 in Human Mast Cells [PDF]

International Journal of Molecular Sciences, 2013
MicroRNA-143 (miR-143) was found to be downregulated in allergic rhinitis, and bioinformatics analysis predicted that IL-13Rα1 was a target gene of miR-143. To understand the molecular mechanisms of miR-143 involved in the pathogenesis of allergic inflammation, recombinant miR-143 plasmid vectors were constructed, and human mast cell-1(HMC-1) cells ...
Yu, Shaoqing, Zhang, Ruxin, Zhu, Chunshen, Cheng, Jianqiu, Wang, Hong, Wu, Jing   +5 more
openaire   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Cytokine tuning of intestinal epithelial function [PDF]

, 2018
The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline, Durum, Scott K., McLean, Mairi H.   +2 more
core   +4 more sources

Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes [PDF]

Journal of Biological Chemistry, 1998
Human B cells stimulated through both their immunoglobulin and CD40 receptors up-regulate 745 +/- 51 interleukin (IL)-13 ligand binding sites with an affinity of 0.91 +/- 0.08 nM within 24 h. IL-13 binds primarily to the IL-13Ralpha1 with subsequent sequestration of the IL-4Ralpha into the complex.
H, Ogata, D, Ford, N, Kouttab, T C, King, N, Vita, A, Minty, J, Stoeckler, D, Morgan, C, Girasole, J W, Morgan, A L, Maizel   +10 more
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source