Results 81 to 90 of about 448,959 (307)

IL‐19 induced by IL‐13/IL‐17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP‐9 expression via ERK/NF‐κB signaling pathway

Clinical and Translational Allergy, 2021
Background Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is crucial for the pathologic tissue remodeling in CRS ...
Xia Li, Jiancong Huang, Xiaohong Chen, Xiaoping Lai, Zizhen Huang, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang   +8 more
doaj   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia, Coste, Sorina Cezara, Cozma, Angela, Negrean, Vasile, Orasan, Olga Hilda, Popovici, Ionela, Procopciuc, Lucia Maria, Sampelean, Dorel, Sitar Taut, Adela, Stefan, Andreea Maria, Tarmure Sarlea, Simina   +10 more
core   +1 more source

Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma [PDF]

International Archives of Allergy and Immunology, 2010
<i>Background:</i> Asthma and rhinitis may represent two manifestations of the same airway disease. Genetic research can increase our understanding of their common or distinct pathogenesis. <i>IL13</i> and <i>IL4R</i> polymorphisms are associated with asthma and show gene-gene interaction in asthma.
Bottema, Renske W. B., Nolte, Ilja M., Howard, Timothy D., Koppelman, Gerard H., Dubois, Anthony E. J., de Meer, Gea, Kerkhof, Marjan, Bleecker, Eugene R., Meyers, Deborah A., Postma, Dirkje S.   +9 more
openaire   +3 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

Journal for ImmunoTherapy of Cancer, 2020
Background The costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as target for cancer therapy.
Alfred Zippelius, Petra Herzig, Heinz Läubli, Vaios Karanikas, Gieri Cathomas, Christian Klein, Marta Trüb, Franziska Uhlenbrock, Christina Claus, Martin Thelen, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Abhishek S Kashyap   +23 more
doaj   +1 more source

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. [PDF]

PLoS ONE, 2017
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive destruction of articular cartilage. Interleukin (IL)-20 is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. We investigated the role of IL-20
Yu-Hsiang Hsu, Ya-Yu Yang, Man-Hsiang Huwang, Yun-Han Weng, I-Ming Jou, Po-Tin Wu, Tain-Yu Lin, Li-Wha Wu, Ming-Shi Chang   +8 more
doaj   +1 more source

Restoration of Tumor Immunosurveillance via Targeting of Interleukin-13 Receptor-α2 [PDF]

Cancer Research, 2008
AbstractIn previous studies, we described a “counter-immunosurveillance” mechanism initiated by tumor-activated, interleukin-13 (IL-13)–producing natural killer T cells that signal Gr-1+ cells to produce transforming growth factor-β1 (TGF-β1), a cytokine that suppresses the activity of tumor-inhibiting cytolytic CD8+ T cells.
Stefan, Fichtner-Feigl, Masaki, Terabe, Atsushi, Kitani, Cheryl A, Young, Ivan, Fuss, Edward K, Geissler, Hans-Jürgen, Schlitt, Jay A, Berzofsky, Warren, Strober   +8 more
openaire   +2 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

IL-13/IL-13Rα2 axis promotes proliferation of angiosarcoma cells

Scientific Reports
Angiosarcoma is a rare and aggressive soft tissue sarcoma with a poor prognosis and limited treatment options. The role of interleukin-13 (IL-13) and its receptors in angiosarcoma pathogenesis has been largely unknown.
Hinako Saito, Jason Yongsheng Chan, Issei Omori, Okuto Iwasawa, Ayaka Sugimori, Hibari Nakajima, Ryuzo Ichimura, Shinichi Sato, Hayakazu Sumida   +8 more
doaj   +1 more source