The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis
Mediators of Inflammation, 2017 The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by ...
Bunsoon Choi +4 more
doaj +1 more source
Inflammation and cell-to-cell communication, two related aspects in frailty
Immunity & Ageing, 2022 Background Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life.
Orietta Pansarasa +5 more
doaj +1 more source
New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors. [PDF]
PLoS ONE, 2013 Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous astrocytomas in dogs resemble human disease and have been proposed as translational model system
Waldemar Debinski +4 more
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Frontiers in Immunology, 2022 Histamine (HA) is a potent mediator that plays a central role in inflammation and allergy, acting through four G-protein-coupled receptors (i.e. H1–H4). HA is an accepted promoter of type 2 immunity in CD4+ T cells during hypersensitivity. Previously, we
Julieta Alcain +7 more
doaj +1 more source
Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
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Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model. [PDF]
PLoS ONE, 2016 The need for new options for chronic lung diseases promotes the research on stem cells for lung repair. Bone marrow-derived mesenchymal stem cells (MSCs) can modulate lung inflammation, but the data on cellular processes involved in early airway ...
Konrad Urbanek +11 more
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Basophils in pruritic skin diseases
Frontiers in Immunology, 2023 Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and ...
Daniela Wiebe +6 more
doaj +1 more source
Cellular networks controlling Th2 polarization in allergy and immunity [PDF]
, 2012 In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam +2 more
core +1 more source
The role of IL-13 gene polymorphism in the exacerbation of Asthma severity
Sokoto Journal of Medical Laboratory Science, 2023 Asthma is a chronic airway inflammatory disorder characterized by persistent airway inflammation, obstruction, and hyper-responsiveness. The role of cytokines, particularly Interleukin-13 (IL-13), in the pathogenesis of asthma has been extensively ...
Kabir, I.M.1, Ibrahim, S.2, Badamasi, I. M.3, Ibrahim H.S.4, Bala J.A.1, Aliyu I.A1*.
doaj
Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]
, 2017 Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio +10 more
core +1 more source