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269 CRITICAL ROLE OF INTERLEUKIN-17 AND INTERLEUKIN-17 RECEPTOR SIGNALING IN TNBS-INDUCED COLITIS.
Journal of Investigative Medicine, 2006Inflammatory bowel diseases (IBD) are characterized by recurrent inflammation in the gastrointestinal tract. Infiltration of CD4+ lymphocytes and neutrophils is one of the predominant features in IBD. Recently, interleukin (IL)-23 and the downstream T-cell derived cytokine IL-17 have been found to be elevated in IBD patients. However, the role of IL-17
Z. Zhang +4 more
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Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis
Oncogene, 2020Interleukin-17 receptor D (IL-17RD), also known as similar expression to Fgf genes (SEF), is proposed to act as a signaling hub that negatively regulates mitogenic signaling pathways, like the ERK1/2 MAP kinase pathway, and innate immune signaling. The expression of IL-17RD is downregulated in certain solid tumors, which has led to the hypothesis that ...
Charlotte Girondel +10 more
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Interleukin-17 receptor D: An orphan receptor finds a home in the skin
Science Immunology, 2019Interleukin-17 receptor D (IL-17RD) heterodimerizes with IL-17RA to form a receptor selective for the cytokine IL-17A. (See the related Research Article by Su et al. )
Allison C. Billi, Johann E. Gudjonsson
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Journal of Investigative Medicine, 2006
Inflammatory bowel diseases (IBD) are characterized by recurrent inflammation in the gastrointestinal tract. Infiltration of CD4+ lymphocytes and neutrophils is one of the predominant features in IBD. Recently, interleukin (IL)-23 and the downstream T-cell derived cytokine IL-17 have been found to be elevated in IBD patients. However, the role of IL-17
Z. Zhang +4 more
openaire +1 more source
Inflammatory bowel diseases (IBD) are characterized by recurrent inflammation in the gastrointestinal tract. Infiltration of CD4+ lymphocytes and neutrophils is one of the predominant features in IBD. Recently, interleukin (IL)-23 and the downstream T-cell derived cytokine IL-17 have been found to be elevated in IBD patients. However, the role of IL-17
Z. Zhang +4 more
openaire +1 more source
Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6
Cellular Signalling, 2007Interleukin-17F (IL-17F), together with interleukin-17A (IL-17 or IL-17A), is a marker of T(H)17 cells, a new lineage of effector CD4(+) T cells to contribute to pathogenesis of a growing list of autoimmune and inflammatory diseases, such as experimental autoimmune encephalitis (EAE) and collagen-induced arthritis (CIA).
Zhili, Rong +8 more
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Interleukin-17 receptor D is a favorable biomarker of glioblastoma
Journal of Neurosurgical SciencesGlioblastoma (GBM) is the most frequent glioma in adults. The prognosis of GBM is very poor and new prognostic biomarkers are in urgent need to better select high-risk patients and guide the individual treatments.In our study, we compared the expression of interleukin-17 receptor D (IL17RD) between GBMs and normal tissues from TCGA database, and ...
Yang, Liu +4 more
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A highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A
Biosensors and Bioelectronics, 2016Interleukin-17 receptor A (IL-17RA) has been recognized as a valuable biomarker for diverse diseases, including autoimmune diseases. In this work, an electrochemical biosensor with great sensitivity and selectivity toward IL-17RA was fabricated using an IL-17RA aptamer (Kd=14.00nM) for the first time.
Hunho Jo +9 more
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Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors
2019The IL-17 family in humans consists of six distinct cytokines (IL-17A-F) that can interact with five IL-17 receptors (IL-17RA-E). The interaction between these cytokines and their receptors are critical in mediating host defenses while also making major contributions to inflammatory and autoimmune responses as demonstrated through both in vitro and in ...
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Functional characterization of interleukin 17 family members and their receptors in amphioxus
International Journal of Biological MacromoleculesThe interleukin 17 (IL17) cytokine family plays a crucial role in phylogenetically conserved immune defense mechanisms, broadly categorized into two distinct evolutionary lineages: the invertebrate-derived (i-type) and vertebrate-specific (v-type) IL17 homologs.
Haifeng, Li +7 more
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Critical Role of Interleukin-17 and Interleukin-17 Receptor Signaling in Tnbs-Induced Colitis
Journal of Investigative Medicine, 2006Z. Zhang +4 more
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