Results 31 to 40 of about 446,523 (309)

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice [PDF]

Scientific Reports, 2015
AbstractBrown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face of hypercaloric diets.
Pazos Mendoza, Patricia, Lima Rodríguez, Luis, Tovar Carro, Sulay A., González Touceda, David, Diéguez González, Carlos, García García, María del Carmen   +5 more
openaire   +3 more sources

NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer

Frontiers in Oncology, 2020
The tumor microenvironment (TME) is crucial in cancer onset, progression and response to treatment. It is characterized by an intricate interaction of immune cells and cytokines involved in tumor development.
Margherita Sonnessa, Antonella Cioffi, Oronzo Brunetti, Nicola Silvestris, Nicola Silvestris, Francesco A. Zito, Concetta Saponaro, Anita Mangia   +7 more
doaj   +1 more source

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +1 more source

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]

, 2008
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus, Claeys, Cindy, Perez Novo, Claudina, Van Cauwenberge, Paul, Waeytens, Anouk   +4 more
core   +2 more sources

Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium

Journal of Reproduction and Development, 2007
Interleukin-18 (IL-18) is a proinflammatory cytokine involved in chronic inflammation, autoimmune diseases, and a variety of cancers, and is expressed in mouse uteri. Our previous study suggested that IL-18 acts as a paracrine factor, regulating endometrial function. To elucidate the physiological roles of IL-18 in the mouse endometrium, the expression
Mariko, Otsuki, Kenji, Kusumoto, Yousuke, Murakami, Munetoshi, Kanayama, Sakae, Takeuchi, Sumio, Takahashi   +5 more
openaire   +3 more sources

Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2011
AbstractIntroductionThere has been no report in the literature of a soluble form of interleukin (IL)-18 receptor α (IL-18Rα). In this study, we evaluated the levels and characteristics of soluble IL-18Rα (sIL-18Rα) in the sera of patients with rheumatoid arthritis (RA) and compared these results to control populations.MethodsThe sIL-18Rα complex was ...
Takei, Satoko, Hoshino, Tomoaki, Matsunaga, Kazuko, Sakazaki, Yuki, Sawada, Masanori, Oda, Hanako, Takenaka, Shin-ichi, Imaoka, Haruki, Kinoshita, Takashi, Honda, Seiyo, Ida, Hiroaki, Fukuda, Taka-aki, Aizawa, Hisamichi   +12 more
openaire   +2 more sources

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Frontiers in Immunology, 2021
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type
Chunren Meng, Chunren Meng, Chufeng Gu, Chufeng Gu, Shuai He, Shuai He, Tong Su, Tong Su, Thashi Lhamo, Deji Draga, Qinghua Qiu, Qinghua Qiu, Qinghua Qiu   +12 more
doaj   +1 more source

Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]

, 2017
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio, Abouzaki, Nayef, Arena, Ross, Biondi-zoccai, Giuseppe, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Dixon, Dave L., Oddi-erdle, Claudia, Trankle, Cory R., Van Tassell, Benjamin W.   +10 more
core   +1 more source

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]

, 2019
Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J, Gingrich, Alicia A, Modiano, Jaime F   +2 more
core   +2 more sources