Results 41 to 50 of about 446,523 (309)
Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling [PDF]
Journal of Biological Chemistry, 1998 We have identified a novel member of the interleukin-1 (IL-1) receptor family, which we have termed AcPL. In transient transfection assays, we were unable to demonstrate a role for AcPL in IL-1-induced activation of NFkappaB. Interleukin-18 (interferon-gamma-inducing factor) is another member of the IL-1 family of cytokines, and it has recently been ...
T L, Born +3 more
openaire +2 more sources
The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis
Mediators of Inflammation, 2017 The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by ...
Bunsoon Choi +4 more
doaj +1 more source
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms [PDF]
Scientific Reports, 2016 AbstractIL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including inflammatory and metabolic diseases, yet relatively little is known regarding its regulation.
Pourcet, Benoit +8 more
openaire +6 more sources
TRAF Regulation of IL-17 Cytokine Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue responses that are crucial for protective immunity but are often implicated in ...
Shadi Swaidani +5 more
doaj +1 more source
NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics
Frontiers in Cell and Developmental Biology, 2022 The NLRP3 inflammasome is a crucial constituent of the body’s innate immune system, and a multiprotein platform which is initiated by pattern recognition receptors (PRRs). Its activation leads to caspase-1 maturation and release of inflammatory cytokines,
Na Lu +8 more
doaj +1 more source
Терапевтический архивAim. To evaluate inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, 8, 6, soluble IL-6 receptors (sIL-6R) and fragmented cytokeratin-18 (FCK-18) as indicators of non-alcoholic steatohepatitis (NASH).
Anastasia A. Shipovskaya +2 more
doaj +1 more source
Pathogens and Dead Cells Cooperate with Cytokines in Activating the Innate and Adaptive Response
European Journal of Inflammation, 2011 After microbial invasion and tissue damage, a set of cytokines, including interleukin-1α (IL-1α), IL-1β, IL-6, IL-18 and tumor necrosis factor-α (TNF-α), and microbial and endogenous molecules named pathogen-associated molecular pattern (PAMPs) and ...
J.E. Belizário
doaj +1 more source
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core +1 more source
Journal of Lipid Research, 1991 Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove +8 more
doaj +1 more source
Tissue signals imprint ILC2 identity with anticipatory function. [PDF]
, 2018 Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L +10 more
core