Results 101 to 110 of about 991,315 (356)

Palm dermatoglyphs and interleukin-4 receptor polymorphisms in asthma

Biomedical Reports, 2016
Single nucleotide polymorphisms (SNPs) in the interleukin-4 receptor (IL-4R) gene have been identified as having a close association with asthma severity in different populations. In our previous studies, a close association between asthma and a distinctive palm dermatoglyphic pattern was observed; however, the clinical implication and underlying ...
Sun, Lixin, Xue, Weilin, Li, Jun, Zhou, Zhaoshan, Han, Wei   +4 more
openaire   +3 more sources

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Expression of hormonal receptors and Toll-like receptors in cultured canine uterine explants with pseudoplacentational endometrial hyperplasia and bacterial-elicited endometrial inflammation.

PLoS ONE
Pseudoplacentational endometrial hyperplasia (PEH) is a common uterine lesion in dogs. A high frequency of pyometra has been associated with PEH in dogs, suggesting that PEH might be related to the pathogenesis of pyometra.
Clarissa Helena Santana, Monique Ferreira Silva Souza, Laice Silva, Lucas Dos Reis Souza, Ayisa Rodrigues Oliveira, Álan Maia Borges, Tatiane Paixão, Renato Lima Santos   +7 more
doaj   +1 more source

B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens.

Journal of Immunology, 1987
Macrophages are activated by lymphokines (LK) to kill tumor cell and microbial targets. Interferon-gamma (IFN) is the major LK activity in conventional, antigen or mitogen-stimulated spleen cell culture fluids for induction of these macrophage effector ...
R. Crawford, D. Finbloom, J. Ohara, W. Paul, M. Meltzer   +4 more
semanticscholar   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Effects of interleukin 4 on neonatal B lymphocyte tolerance [PDF]

, 1989
Perturbation of antigen receptors on mouse neonatal B cells by rabbit anti-mouse IgM antibody was shown to inhibit cell proliferation in response to the B cell mitogen lipopolysaccharide.
Richard L. Riley, James S. Peacock, Valerian B. Pinto, Peacock, James S, Pinto, Valerian B, Riley, Richard L   +5 more
core   +1 more source

IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes

Frontiers in Endocrinology
IntroductionAlthough interleukin receptors have been implicated in various autoimmune diseases, their role in type 1 diabetes (T1D) remains underexplored and occasionally inconsistent.
Cintia Semzezem, Karla Fabiana Brasil Gomes, Aritania Sousa Santos, Pauline Brochet, Lindiane Gomes Crisostomo, Marcia Regina Soares Correia, Amanda Farage Frade-Barros, Luciano Abreu Brito, Maria Rita Passos-Bueno, Christophe Chevillard, Edecio Cunha-Neto, Maria Elizabeth Rossi da Silva   +11 more
doaj   +1 more source

Augmentation by Bursaphelenchus xylophilus, a Pine Wood Nematode, of Polyclonal IgE Production Induced by Lipopolysaccharide Plus Interleukin-4 in Murine Splenocytes

Journal of Pharmacological Sciences, 2003
Bursaphelenchus xylophilus (B. xylophilus) is a pine wood nematode that is known to cause pine wilt disease. We report here that B. xylophilus extracts augmented the polyclonal immunoglobulin E (IgE) production induced by lipopolysaccharide (LPS) plus ...
Hiroaki Kaji, Masahiko Kawada, Akihiro Tai, Hiroshi Kanzaki, Itaru Yamamoto   +4 more
doaj   +1 more source

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells

Journal of Experimental Medicine, 1996
Natural Killer (NK)1.1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that are normally associated with the NK cell lineage of the innate immune system.
A. Bendelac, R. Hunziker, O. Lantz
semanticscholar   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source