Results 111 to 120 of about 99,631,586 (306)

Exploring the Potential of Receptor Silencing in the Tumor Microenvironment by RNA Interference

Biomolecules
Cancer is a heterogeneous disease caused by genetic and epigenetic factors, leading to alterations in signaling pathways and regulatory processes. Overall, the more commonly employed conventional treatments present side effects and resistance. Due to the
Karina Mayumi Tani Bezerra de Melo, Beatriz Mendonça Alves Bandeira, Pedro Vinícius Silva Novis, Micaela Evellin dos Santos Silva, Ingrid Andrêssa de Moura, Antonio Carlos de Freitas, Anna Jéssica Duarte Silva   +6 more
doaj   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD

Mediators of Inflammation, 2013
Obesity is associated with chronic low-grade inflammation perpetuated by visceral adipose. Other organs, particularly stomach and intestine, may also overproduce proinflammatory molecules.
Rohini Mehta, Aybike Birerdinc, Arpan Neupane, Amirhossein Shamsaddini, Arian Afendy, Hazem Elariny, Vikas Chandhoke, Ancha Baranova, Zobair M. Younossi   +8 more
doaj   +1 more source

Interleukin-4 serum concentrations of dogs fed control or supplemented diet with beta-glucan.

, 2018
Values determined before vaccination (time 0), seven days after the first dose of vaccine (time 7) and 21 days after the first dose of vaccine (time 21). IL-4: interleukin-4.
Karen Guttenkunst Lisenko (5575100), Lívia Geraldi Ferreira (5575094), Márcio Gilberto Zangeronimo (4771806), Flávia Maria de Oliveira Borges Saad (5575118), Ana Paula Peconick (5575115), Mariangela Endrighi (5575097), Maiara Rodrigues Duarte de Oliveira (5575103), Pamella Godinho Gutierres (5575112), Mateus Resende Damasceno (5575106), Jelieny Aparecida Claudino (5575109)   +9 more
core   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Microglia express GABAB receptors to modulate interleukin release

, 2004
γ-Aminobutyric acid (GABA) can act as a neuroprotective agent besides its well-established role as the main inhibitory neurotransmitter in the CNS.
Van Landeghem, F.K., Kettenmann, H., Zacharias, R., Faerber, K., Rappert, A., Hoffmann, A., Nolte, C., Kuhn, S.A., Pavlovic, S.   +8 more
core   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

EP 4 receptors mediate prostaglandin E 2, tumour necrosis factor alpha and interleukin 1beta-induced ion secretion in human and mouse colon mucosa

, 2012
EP 4 receptors mediate prostaglandin E 2, tumour necrosis factor alpha and interleukin 1beta-induced ion secretion in human and mouse colon ...
SE Fairbrother (14474910), HM Cox (14474847), JE Smith (7757447), RA Borman (14474913)   +3 more
core  

Real‐World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA). Methods This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan   +28 more
wiley   +1 more source

Protease‐Activated Theranostic Nanomedicine for Endometriosis Treatment

Advanced Functional Materials, EarlyView.
Endometriosis is a chronic gynecological disorder that affects a substantial proportion of reproductive‐aged women. In this study, we identify aberrant overexpression of matrix metalloproteinase‐9 (MMP‐9) in endometriotic lesions and develop a novel multifunctional nanomedicine that integrates MMP‐9‐targeted therapy, ratiometric photoacoustic (PA ...
Panangattukara Prabhakaran Praveen Kumar, Tae Hoon Kim, Hossein Hosseinirad, Maggie Lee, HyeJoo An, Bruce A. Lessey, Daniel Hanavi, Jung‐Ho Shin, Jae‐Wook Jeong, Taeho Kim   +9 more
wiley   +1 more source