Results 11 to 20 of about 991,315 (356)

Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases [PDF]

Genes & Immunity, 2001
Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine production from Th1 lymphocytes. Functionally relevant polymorphisms have been described in the interleukin-4 and the interleukin-4 receptor alpha genes.
W, Klein, A, Tromm, T, Griga, H, Fricke, C, Folwaczny, M, Hocke, K, Eitner, M, Marx, N, Duerig, J T, Epplen   +9 more
openaire   +2 more sources

IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma [PDF]

PeerJ, 2022
Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid.
Siti Muhamad Nur Husna, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong   +3 more
doaj   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

A Case of Papuloerythroderma Successfully Treated with Dupilumab

Case Reports in Dermatology, 2022
Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching.
Ayaka Mizuno, Koji Habe, Yoshiaki Matsushima, Makoto Kondo, Keiichi Yamanaka   +4 more
doaj   +1 more source

Human basophils express interleukin-4 receptors [PDF]

Blood, 1990
Abstract Interleukin-4 (IL-4), a multipotential lymphokine reputed to play an important role in the regulation of immune responses, interacts with a variety of hemopoietic target cells through specific cell surface membrane receptors. The present study was designed to investigate whether human basophils express IL-4 binding sites.
P, Valent, J, Besemer, K, Kishi, F, Di Padova, K, Geissler, K, Lechner, P, Bettelheim   +6 more
openaire   +3 more sources

Differential effects of age on chicken heterophil functional activation by recombinant chicken interleukin-2 [PDF]

, 2002
Interleukin-2 (IL-2) exercises an array of biological effects on many cells including the functional activation of cells of the innate immune response.
Pete Kaiser, Kogut, Michael, Michael Kogut, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction [PDF]

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

Systemic inflammation in patients with chronic obstructive pulmonary disease and obesity [PDF]

Терапевтический архив, 2020
Chronic obstructive pulmonary disease (COPD) is an important public health problem. According to various studies, the prevalence of obesity in patients with COPD is as high as 50%. Aim.
E. S. Ovsyannikov, S. N. Avdeev, A. V. Budnevsky   +2 more
doaj   +1 more source

Stoichiometry of the complex of human interleukin‐4 with its receptor [PDF]

FEBS Letters, 1994
A large number of cytokines have been shown to possess a four‐helix bundle structure with a unique up‐up‐down‐down connectivity. The receptors for this family of cytokines have been shown to be homologous as well, each possessing two tandem repeats of a fibronectin type III‐like domain. The crystal structure of human growth hormone bound to the soluble
Hoffman, Ross C., Schalk-Hihi, Céline, Castner, Beverly J., Gibson, Marylou G., Rasmussen, Brian D., Zdanov, Alexander, Gustchina, Alla, March, Carl J., Wlodawer, Alexander   +8 more
openaire   +2 more sources

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
core   +1 more source