Results 31 to 40 of about 1,081,549 (346)

Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.

Journal of Biological Chemistry, 1991
Human interleukin (IL)-5 receptors were characterized by means of binding studies using bioactive 125I-labeled IL-5. Of purified primary myeloid cells, eosinophils and basophils but not neutrophils or monocytes expressed surface receptors for IL-5 ...
Angel F. Lopez, Mathew A. Vadas, J. Woodcock, Susan E. Milton, Andrew Lewisll, Michael, J., Elliott, D. Gillis, Robin IrelandTl, Eileen OlwelllI, Linda S. Parkll   +11 more
semanticscholar   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice

Neurobiology of Stress, 2019
The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility.
Joshua McWhirt, Monica Sathyanesan, Dayalan Sampath, Samuel S. Newton   +3 more
doaj   +1 more source

Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury

Bioactive Materials, 2023
Acute myocardial infarction (AMI) induces a sterile inflammatory response, leading to cardiomyocyte damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays an essential role in developing eosinophils (EOS), which are beneficial for the ...
Dongjian Han, Fuhang Wang, Zhentao Qiao, Bo Wang, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Yuansong Zhuang, Quanxu An, Yan Bai, Jiahong Shangguan, Jinying Zhang, Gaofeng Liang, Deliang Shen   +13 more
doaj   +1 more source

Identification of a Cys Motif in the Common β Chain of the Interleukin 3, Granulocyte-Macrophage Colony-stimulating Factor, and Interleukin 5 Receptors Essential for Disulfide-linked Receptor Heterodimerization and Activation of All Three Receptors*

Journal of Biological Chemistry, 1998
The human interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors undergo covalent dimerization of the respective specific α chains with the common β subunit (βc) in the presence of the cognate ligand.
F. Stomski, J. Woodcock, B. Zacharakis, C. Bagley, Qiyu Sun, A. Lopez   +5 more
semanticscholar   +1 more source

Pharmacogenetics of antidepressants

Frontiers in Pharmacology, 2011
Up to 60% of depressed patients do not respond completely to antidepressants (AD) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes
Concetta eCrisafulli, Chiara eFabbri, Stefano ePorcelli, Antonio eDrago, Edoardo eSpina, Diana eDe Ronchi, Alessandro eSerretti   +6 more
doaj   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Multisite Mutagenesis of Interleukin 5 Differentiates Sites for Receptor Recognition and Receptor Activation [PDF]

Biochemistry, 2000
Multisite mutagenesis of single-chain and monomeric forms of human interleukin 5 (IL-5) was performed to investigate mechanistic features of receptor activation and the possibility of differentiating sites of activation from those for receptor interaction. The normally dimeric human IL-5 contains two domains, each containing a four-helix bundle.
C G, Plugariu, S J, Wu, W, Zhang, I, Chaiken   +3 more
openaire   +2 more sources

FEATURES OF THE RECEPTORS EXPRESSION FOR INTERLEUKIN 4 AND 5 IN THE FORMATION OF THE ATOPIC STATUS IN NEWBORNS

Педиатрическая фармакология, 2011
Identification of the early markers of the onset of atopic march in children remains important for the effective primary and secondary prevention of allergic diseases.
T.V. Turti, E.L. Semikina, L.S. Namazova-Baranova   +2 more
doaj   +2 more sources

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell Reports, 2014
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia ...
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez   +18 more
doaj   +1 more source