Results 11 to 20 of about 1,081,549 (346)

Involvement of 5HT3 Receptors in Anti-Inflammatory Effects of Tropisetron on Experimental TNBS-Induced Colitis in Rat [PDF]

BioImpacts, 2013
Introduction: There is a pressing need for research leading to the development of new effective drugs with lower side effects and more efficacy for treating inflammatory bowel disease (IBD).
Azadeh Motavallian, Mohsen Minaiyan, Mohammad Rabbani, Sasan Andalib, Parvin Mahzouni   +4 more
doaj   +1 more source

Permethrin induced arterial retention of native and oxidized LDL in rats by promoting inflammation, oxidative stress and affecting LDL receptors, and collagen genes

Ecotoxicology and Environmental Safety, 2021
This study is the first to examine the possible mechanism by which long-term exposure to permethrin (PER) can promote arterial retention of proatherogenic lipid and lipoproteins and related vascular dysfunction in rats.
Anouar Feriani, Meriam Tir, Rafik Hachani, Mohamed Salah Allagui, Nizar Tlili, Saber Nahdi, Saleh Alwasel, Abdel Halim Harrath   +7 more
doaj   +1 more source

The role of polymorphism of genes IL5 (–703) and IL5RA (–80) in formation of blood eosinophilia under pulmonary tuberculosis

Бюллетень сибирской медицины, 2012
With attracting contemporary molecular-genetic and immunological research methods, the article analyses etiopathogenetical factors of formation of eosinophilic blood reaction under pulmonary tuberculosis.
K. O. Mikheyeva, V. V. Novitsky, O. I. Urazova, Yu. V. Kolobovnikova, M. D. Goncharov, I. O. Naslednikova   +5 more
doaj   +1 more source

Length-Dependent Modulation of B Cell Activating Factor Transcripts in Chicken Macrophage by Viral Double-Stranded RNA

Vaccines, 2023
Viral double-stranded RNA (dsRNA) interacts with Retinoic-acid-inducible-gene-1 (RIG-1)-like receptors (RLRs) to induce type 1 interferons. Melanoma-derived-antigen-5 (MDA-5), an RLR, but not RIG-1, is found in chickens.
Magda I. Abo-Samaha, Mohammed M. Sharaf, Abeer F. El-Nahas, Solomon O. Odemuyiwa   +3 more
doaj   +1 more source

Interleukin-5 and Interleukin-5 Receptor Polymorphism in Asthma

, 2023
Asthma is a common chronic inflammatory disease of the airways of the lungs, in the world. It’s associated with type 2 cytokines interleukin-4, IL-5, and IL-13, which promote airway eosinophilia, bronchial hyperresponsiveness, mucus overproduction, and immunogloubulin E synthesis.
Maytham, Hameed, Raghdah, Najim, Abood, Haidar Abdul Amir, Mohsin, Ahmed, Mohanad   +2 more
openaire   +2 more sources

Receptor Epitope Usage by an Interleukin-5 Mimetic Peptide [PDF]

Journal of Biological Chemistry, 2005
The cyclic peptide AF17121 is a library-derived antagonist for human interleukin-5 (IL5) receptor alpha (IL5Ralpha) and inhibits IL5 activity. Our previous results have demonstrated that the sixth arginine residue of the peptide is crucial for the inhibitory effect and that several acidic residues in the N- and C-terminal regions also make a ...
Tetsuya, Ishino, Cecilia, Urbina, Madhushree, Bhattacharya, Dominick, Panarello, Irwin, Chaiken   +4 more
openaire   +2 more sources

Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs

Current Opinion in Allergy and Clinical Immunology, 2016
Purpose of reviewHuman eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cell's granular uptake of eosin. Although eosinophils represent approximately 1% of peripheral blood leukocytes, they have the propensity to ...
G. Varricchi, D. Bagnasco, F. Borriello, E. Heffler, G. Canonica   +4 more
semanticscholar   +1 more source

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells

Journal of Experimental Medicine, 1990
The T cell product interleukin 5 (IL-5) has been shown to be a key factor in the development and the maturation of the eosinophilic cell lineage. We report here on the detection of human IL-5 receptors on eosinophilic sublines of the promyelocytic ...
G. Plaetinck, J. Heyden, J. Tavernier, Ina Fache, T. Tuypens, Steven A. Fischkoff, Walter Fiers, Rene Devos   +7 more
semanticscholar   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains [PDF]

Proceedings of the National Academy of Sciences, 2000
Two series of peptides that specifically bind to the extracellular domain of the α chain of the human interleukin-5 receptor (IL-5Rα), but share no primary sequence homology to IL-5, were identified from libraries of random recombinant peptides. Affinity maturation procedures generated a 19-aa peptide that binds to the IL-5 receptor α/β heterodimer ...
B P, England, P, Balasubramanian, I, Uings, S, Bethell, M J, Chen, P J, Schatz, Q, Yin, Y F, Chen, E A, Whitehorn, A, Tsavaler, C L, Martens, R W, Barrett, M, McKinnon   +12 more
openaire   +2 more sources