Results 21 to 30 of about 1,081,549 (346)

Suppression of interleukin-1 beta and LDL scavenger receptor expression in macrophages by a selective protein kinase C inhibitor.

Journal of Lipid Research, 1991
A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (
AL Akeson, K Schroeder, C Woods, CJ Schmidt, W D Jones   +4 more
doaj   +1 more source

Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children

Frontiers in Immunology, 2018
Lower respiratory tract infections (LRTI) are often caused by Streptococcus pneumoniae (Spn) and can be recurrent in 8% of children older than 2 years of age.
Johan N. Siebert, Johan N. Siebert, Lutz Hamann, Charlotte M. Verolet, Cécile Gameiro, Stéphane Grillet, Claire-Anne Siegrist, Claire-Anne Siegrist, Claire-Anne Siegrist, Klara M. Posfay-Barbe, Klara M. Posfay-Barbe   +10 more
doaj   +1 more source

Nicotinamide inhibits melanoma in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2020
Background Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the amide form of Niacin, was ...
Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano, Antonio Facchiano   +8 more
doaj   +1 more source

A computational analysis of transcriptional profiles from CD8(+) T lymphocytes reveals potential mechanisms of HIV/AIDS control and progression

Computational and Structural Biotechnology Journal, 2021
Cytotoxic and noncytotoxic CD8+ T lymphocyte responses are essential for the control of HIV infection. Understanding the mechanisms underlying HIV control in elite controllers (ECs), which maintain undetectable viral load in the absence of antiretroviral
Sergey Ivanov, Dmitry Filimonov, Olga Tarasova   +2 more
doaj   +1 more source

Involvement of p59fynT in interleukin-5 receptor signaling. [PDF]

The Journal of experimental medicine, 1995
Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in
M W, Appleby, J D, Kerner, S, Chien, C R, Maliszewski, S, Bondada, R M, Perlmutter, S ], Bondadaa S [corrected to Bondada   +6 more
openaire   +2 more sources

Chromosomal localization and organization of the murine genes encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors.

Journal of Biological Chemistry, 1992
Chromosomal genes for two mouse homologous beta subunits (AIC2A and AIC2B) of the interleukin-3, granulocyte/macrophage colony-stimulating factor, and interleukin-5 receptors were characterized.
D. Gorman, N. Itoh, N. Jenkins, D. Gilbert, N. G. Copeland, Atsushi Miyajima   +5 more
semanticscholar   +1 more source

Expression of serotonin 2A, 2C, 6 and 7 receptor and IL-6 mRNA in experimental toxoplasmic encephalitis in mice

Heliyon, 2019
The neurotropic pathogen Toxoplasma gondii infects about one-third of the human population. Both acute and chronic (latent or life-long) forms of toxoplasmosis are associated with specific neurologic and neuropsychiatric symptoms.
Hasan Tarik Atmaca
doaj   +1 more source

Novel Biological Therapies for Severe Asthma Endotypes

Biomedicines, 2022
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini, Alessandro Vatrella   +8 more
doaj   +1 more source

Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects

Journal of Pharmacological Sciences, 2004
The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats.
Fu-Shin Chueh, Ching-Ping Chang, Chung-Ching Chio, Mao-Tsun Lin   +3 more
doaj   +1 more source

Reconstitution of the functional receptors for murine and human interleukin 5

Journal of Experimental Medicine, 1993
The murine interleukin 5 receptor (mIL-5R) is composed of two distinct subunits, alpha and beta. The alpha subunit (mIL-5R alpha) specifically binds IL-5 with low affinity.
Satoshi Takaki, Yoshiyuki Murata, Toshio Kitamura, Atsushi Miyaj, Akira Tominaga, Kiyoshi Takatsu   +5 more
semanticscholar   +1 more source