Results 21 to 30 of about 299,590 (247)

Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes

Journal of Pharmacological Sciences, 2006
UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells.
Daisaku Kobayashi, Satoko Ohkubo, Norimichi Nakahata   +2 more
doaj   +1 more source

Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. [PDF]

PLoS ONE, 2015
Extracellular nucleotides, such as ATP, are released from cells in response to various stimuli and act as intercellular signaling molecules through activation of P2 receptors.
Ayumi Kawano, Remi Kadomatsu, Miyu Ono, Shuji Kojima, Mitsutoshi Tsukimoto, Hikaru Sakamoto   +5 more
doaj   +1 more source

Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
openaire   +2 more sources

Morphine Attenuates Apically-Directed Cytokine Secretion from Intestinal Epithelial Cells in Response to Enteric Pathogens

Pathogens, 2014
Epithelial cells represent the first line of host immune defense at mucosal surfaces. Although opioids appear to increase host susceptibility to infection, no studies have examined opioid effects on epithelial immune functions.
Amanda J. Brosnahan, Bryan J. Jones, Cheryl M. Dvorak, David R. Brown   +3 more
doaj   +1 more source

Cortisol Dose-Dependently Impairs Migration and Tube-like Formation in a Trophoblast Cell Line and Modulates Inflammatory and Angiogenic Genes

Biomedicines, 2021
Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself.
Talita Guerreiro Rodrigues Húngaro, Marcos F. Gregnani, Thaís Alves-Silva, Florian Herse, Natalia Alenina, Michael Bader, Ronaldo C. Araújo   +6 more
doaj   +1 more source

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Frontiers in Genetics
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β ...
Jia-wei Ma, Jia-wei Ma, Ji-chun Tang, Hong-zhi Fang   +3 more
doaj   +1 more source

Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action

Research in Pharmaceutical Sciences, 2021
Background and purpose: Kaempferol (KM), a flavonoid, has an anti-inflammatory and anticancer effect and prevents many metabolic diseases. Nonetheless, very few studies have been done on the antinociceptive effects of KM. This research aimed at assessing
Sajjad Jabbari, Maryam Bananej, Mohammad Zarei, Alireza Komaki, Ramin Hajikhani   +4 more
doaj   +1 more source

Effects of ulinastatin on global ischemia via brain pro-inflammation signal

Translational Neuroscience, 2016
Ulinastatin [urinary trypsin inhibitor (UTI)] plays an important role in the protection of organs against ischemic injury during severe inflammation.
Jiang Xiao-Ming, Hu Jing-Hai, Wang Lu-Lu, Ma Chi, Wang Xu, Liu Xiao-Liang   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source