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The family of the interleukin‐1 receptors
Immunological Reviews, 2017SummaryThe extracellular forms of the IL‐1 cytokines are active through binding to specific receptors on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand‐binding receptor chain. For signaling to take place, a non‐binding accessory chain is recruited into a heterotrimeric complex.
Boraschi +4 more
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Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist
International Reviews of Immunology, 1998IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
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1995
Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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Biochemical and Biophysical Research Communications, 1993
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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The interleukin 1 receptor family
Developmental & Comparative Immunology, 2004Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region.
Sumathi, Subramaniam +2 more
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Interleukin 5 and its receptor
Progress in Growth Factor Research, 1991IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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The human interleukin-2 receptor
Journal of Cell Science, 1985ABSTRACT Complementary DNAs corresponding to the human receptor for interleukin-2 (IL-2) have been molecularly cloned, sequenced, and expressed in both COS-1 and L cells. The human genome appears to contain a single structural gene for this receptor located on the short arm of chromosome 10 (band 14-15).
W C, Greene +3 more
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The Human Interleukin-2 Receptor
Annual Review of Immunology, 1986In 1976, Morgan et al first reported the presence of a T-cell growth promoting activity in the supernatants of activated T-cell cultures; they denoted this T-cell growth factor (TCGF) (1). In subsequent years, TCGF was characterized as a distinct biochemical entity and found to be a 15,500dalton glycoprotein (2).
W C, Greene, W J, Leonard
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Biology of the Interleukin-2 Receptor
1998Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the interactions among vast numbers of lymphocytes, comprising a number of functionally distinct ...
B H, Nelson, D M, Willerford
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INTERLEUKIN-1 RECEPTOR ANTAGONIST
Rheumatic Disease Clinics of North America, 1998There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells.
B, Bresnihan, G, Cunnane
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