Results 171 to 180 of about 1,112,126 (259)
The Effect of Manipulating the IL-6 Response to Exercise on Biomarkers and Exercise Performance [PDF]
Interleukin-6 (IL-6) is a pluripotent cytokine which has inflammatory properties. It is suggested to mediate a variety of processes including increased perception of fatigue during inflammatory states.
Walshe, Ian
core
Microglia and immune signaling as architects of the brain. [PDF]
Front Cell NeurosciKim A, Solek CM, Ruthazer ES.
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
Inflammatory immune mechanisms underlying the comorbidity of psoriasis and atherosclerosis: clinical implications. [PDF]
Front ImmunolXin W, Tian Y, Wang S, Zhang S, Chen Z.
europepmc +1 more source
Advanced Science, EarlyView.Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian +10 more
wiley +1 more source
Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases. [PDF]
MedComm (2020)Deng K, Chong WP.
europepmc +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Statement of Retraction: MicroRNA-155-5p modulates the progression of acute respiratory distress syndrome by targeting interleukin receptors. [PDF]
Bioengineeredeuropepmc +1 more source