Results 161 to 170 of about 1,058,709 (203)

Graves' ophthalmopathy and gene polymorphisms in interleukin‐1α, interleukin‐1β, interleukin‐1 receptor and interleukin‐1 receptor antagonist

Clinical & Experimental Ophthalmology, 2009
AbstractPurpose:  Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and
Omid, Khalilzadeh, Mehdi, Anvari, Alireza, Esteghamati, Mahdi, Mahmoudi, Maryam, Tahvildari, Armin, Rashidi, Farideh, Khosravi, Aliakbar, Amirzargar   +7 more
openaire   +2 more sources

Interleukin-3 and its receptor

1995
Cytokines are actively involved in the host-defense system to coordinate the functional activity and the generation of effector cells. Some of these molecules function as inflammatory mediators and hematopoietic growth factors at the same time such as IL-1, IL-6, IL-3, IL-5, and GM-CSF.
Lindemann, Albrecht, Mertelsmann, Roland
openaire   +2 more sources

The effects of blockade of interleukin 2 receptors and interleukin 4 receptors on cytokine production

APMIS, 1991
The understanding of the regulation of cytokine production and T‐cell proliferation by other cytokines is far from complete. We have examined the supernatant concentration of different cytokines in cultured peripheral blood lymphocytes (PBL) incubated with monoclonal antibodies against the interleukin‐2 receptor (IL‐2R) or interleukin‐4 receptor (IL‐4R)
Lai, KN, Leung, JCK, Larche, M, Ritter, MA, Li, PKT   +4 more
openaire   +4 more sources

Involvement of gp130/interleukin‐6 receptor transducing component in interleukin‐11 receptor

European Journal of Immunology, 1994
AbstractThe recently cloned interleukin (IL)‐11 displays many biological properties in common with those reported for IL‐6. In order to analyze the nature and the functionality of the IL‐11 receptor we developed a proliferative assay using the human multifactor‐dependent cell line TF1.
M, Fourcin, S, Chevalier, J J, Lebrun, P, Kelly, A, Pouplard, J, Wijdenes, H, Gascan   +6 more
openaire   +2 more sources

Interleukin-1 Receptor Antagonist

1993
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
openaire   +2 more sources

Blocking interleukin-1 receptors

International Journal of Clinical & Laboratory Research, 1994
During inflammation, injury, immunological challenge or infection, interleukin-1 appears to mediate, in part, the pathogenesis, of disease. Most studies on interleukin-1 are derived from experiments in which bacterial products, such as endotoxins from Gram-negative bacteria or exotoxins from Gram-positive organisms, are used to stimulate macrophagic ...
openaire   +2 more sources

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

Circulation Research, 2021

exaly  

The interleukin-1/interleukin-1-receptor interaction

Annales de l'Institut Pasteur / Immunologie, 1987
H R, MacDonald, J W, Lowenthal
openaire   +2 more sources

Biology and therapeutic potential of interleukin-10

Journal of Experimental Medicine, 2020
Anne O'Garra, Margarida Saraiva, Paulo Vieira   +2 more
exaly  

Interleukin-2 and the Interleukin-2 Receptor Complex

2015
G N, Gaulton, P, Williamson
openaire   +2 more sources