Results 181 to 190 of about 341,836 (251)
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A physiologically active kainic acid-preferring receptor in chicken retina
Neuroscience Letters, 1984Neurotoxicity induced by intravitreal injections of kainic acid in the chicken retina was effectively antagonized by piperidine 2,3-dicarboxylic acid and to a lesser extent D-gamma-glutamylglycine. 2-Amino-5-phosphonovaleric acid and glutamic acid diethyl ester were much less effective antagonists. These effects probably result from interactions with a
I G, Morgan, D R, Dvorak
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Kainic Acid‐Induced Decrease in Hippocampal Corticosteroid Receptors
Journal of Neurochemistry, 1992Abstract: The potential role of excitatory amino acids in the regulation of brain corticosteroid receptors was examined using systemic administration of kainic acid. Administration of kainic acid (5, 10, and 15 mg/kg) to 24‐h adrenalectomized rats that were killed 3 h later produced large, dose‐related decreases in glucocorticoid receptors (GR) in ...
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Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity
Experimental Neurology, 1990Domoic acid (Dom), a rigid analog of the excitotoxic amino acids, glutamate and kainic acid, is believed to be the mussel neurotoxin responsible for a recent food poisoning incident in Canada that killed some people and left others with memory impairment.
G R, Stewart +3 more
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Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites
Neuroscience Letters, 1988The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively.
A, Skattebøl +3 more
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Kainic Acid: Insights Into Its Receptor-Mediated Neurotoxic Mechanisms
1983Historically, kainic acid (KA) was selected as a potential exitotoxin because the evidence at the time was consistent with the notion that, as a conformationally restricted analogue of L-glutamate, it was a potent agonist at glutamate receptors (Olney et al., 1974; Coyle and Schwarcz, 1976). Since the first reports of the perikaryal-specific neurotoxic
J. T. Coyle +4 more
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Analogue interactions with the brain receptor labeled by [3H]kainic acid
Brain Research, 1983The kinetics of interaction of kainic acid analogues and reputed antagonists of acidic excitatory amino acids with a specific binding site for [3H]alpha-kainic acid were examined in washed cerebellar membranes incubated at 4 degrees C. The avidity of both L-glutamate (1.5 microM) and quisqualate (0.6 microM) suggests that proper orientation of the two ...
J T, Slevin, J F, Collins, J T, Coyle
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Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection
Hippocampus, 2011AbstractWe recently demonstrated that endogenous prodynorphin‐derived peptides mediate anticonvulsant, antiepileptogenic and neuroprotective effects via kappa opioid receptors (KOP). Here we show acute and delayed neurodegeneration and its pharmacology after local kainic acid injection in prodynorphin knockout and wild‐type mice and neuroprotective ...
Eduard, Schunk +5 more
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Fructose ingestion modifies NMDA receptors and exacerbates the seizures induced by kainic acid
Neuroscience Letters, 2022Fructose ingestion elicits a diversity of brain alterations, but it is unknown how it affects N-methyl-D-Aspartate receptors (NMDAr). Here, we analyzed the expression of NMDAr subunits and protein kinases after the long-term dietary fructose intake.
Josué, Sánchez-Hernández +3 more
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Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue
Brain Research, 1980The phylogenetic distribution of specific binding sites for kainic acid was determined in 14 species including invertebrates and vertebrates. The highest level of binding was observed in brains of the frog (Xenopus laevis), followed by the spiny dogfish (Heterodontus francisci), the goldfish (Carasius auratus) and the chick (Gallus domesticus ...
E D, London, N, Klemm, J T, Coyle
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Neurochemistry International, 1987
Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the left when [Ca(2+)] was lowered to 0 ...
VERSACE, PAOLA +3 more
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Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the left when [Ca(2+)] was lowered to 0 ...
VERSACE, PAOLA +3 more
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