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Autoradiographic visualization of [3H]kainic acid receptor subtypes in the rat hippocampus
Neuroscience Letters, 1983Unfixed, slide-mounted tissue sections from the rat forebrain have been incubated in the presence of 20 and 100 nM [3H]kainic acid ([3H]KA). For the last 2 min of incubation, 10 micrometers unlabelled KA was added to displace [3H]KA from binding sites with high on-off rate. Washed and dried slices were exposed on [3H]Ultrofilm for 178 days. Our results
M, Berger, Y, Ben-Ari
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Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design
Medicinal Research Reviews, 2008Abstract(S)‐Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system, activating the plethora of glutamate receptors (GluRs). In broad lines, the GluRs are divided into two major classes: the ionotropic Glu receptors (iGluRs) and the metabotropic Glu receptors (mGluRs).
Bunch, Lennart, Krogsgaard-Larsen, Povl
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Kainic Acid Modifies μ-Receptor Binding in Young, Adult, and Elderly Rat Brain
Cellular and Molecular Neurobiology, 2002Mu-receptor binding changes were evaluated following the kainic acid (KA)-induced status epilepticus (SE) in young, adult, and elderly animals. Male Wistar rats were used as follows: young rats (15 days old) were treated with KA (7 mg/kg) and sacrificed 72 h (YKA3d) or 35 days (YKA35d) after SE; adult (90 days old) (AKA1d and AKA40d) and elderly rats ...
Claudia, Pérez-Cruz, Luisa, Rocha
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TNF‐α receptor 1 deficiency enhances kainic acid–induced hippocampal injury in mice
Journal of Neuroscience Research, 2008AbstractThe exact role of TNF‐α in excitotoxic neurodegeneration of the brain is unclear. To address this issue, the kainic acid (KA)–induced hippocampal injury model, a well‐characterized model of human neurodegenerative diseases, was used in TNF‐α receptor 1 (TNFR1)–knockout (TNFR1−/−) mice in the present study.
Ming-Ou, Lu +6 more
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The molecular characterization of a putative kainic acid receptor.
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada, 1991The purification of a putative kainic acid receptor has been accomplished by the development of a domoic acid affinity column. Domoic acid, immobilized through the carboxylic acid groups, retains the ability to bind kainic acid receptors in solution. The purified receptor from frog brain migrates as a diffuse band centred at a relative molecular weight
D R, Hampson +2 more
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Neurotoxicology, 1990
[3H]Quinuclidinyl benzilate (QNB) binding to muscarinic receptors decreased in the rat forebrain after convulsions induced by a single dose of either soman, a potent inhibitor of acetylcholinesterase, or kainic acid, an excitotoxin. A Rosenthal plot revealed that the receptors decreased in number rather than affinity. When the soman-induced convulsions
L, Churchill +4 more
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[3H]Quinuclidinyl benzilate (QNB) binding to muscarinic receptors decreased in the rat forebrain after convulsions induced by a single dose of either soman, a potent inhibitor of acetylcholinesterase, or kainic acid, an excitotoxin. A Rosenthal plot revealed that the receptors decreased in number rather than affinity. When the soman-induced convulsions
L, Churchill +4 more
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Effect of kainic acid on striatal dopamine receptors
Brain Research, 1980P, Weinreich, P, Seeman
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